Metabolic phenotype in COPD
- Conditions
- Health Condition 1: J449- Chronic obstructive pulmonary disease, unspecified
- Registration Number
- CTRI/2018/01/011441
- Lead Sponsor
- Chest Research Foundation
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 75
ï?· Healthy non-smoker
o Be at least 40 years of age
o Provide written informed consent
o Never smoker and not exposed to biomass for >10 years
o No major abnormality on clinical examination
o Normal spirometry, FEV1/FVC >0.70
ï?· Healthy smoker
o Be at least 40 years of age
o Provide written informed consent
o Be smoking tobacco in the form of bidi or cigarettes for at least 10 pack years
o No major abnormality on clinical examination
o Normal spirometry, FEV1/FVC >0.70
4
ï?· Healthy Biomass user
o Be at least 40 years of age
o Provide written informed consent
o Be exposed to biomass for at least 10 fuel-years (exposure of 2hrs/day for 10 years)
after adulthood
o No major abnormality on clinical examination
o Normal spirometry, FEV1/FVC >0.70
ï?· Tobacco smoking COPD
o Be at least 40 years of age
o Provide written informed consent
o Be smoking tobacco in the form or bidi or cigarettes for at least 10 pack-years
o Have a clinical diagnosis of COPD (GOLD stage I to III) and post-bronchodilator
FEV1/FVC ratio <0.70)
ï?· Non-smoking COPD
o Be at least 40 years of age
o Provide written informed consent
o Be exposed to biomass for at least 10 fuel-years after adulthood
o Have a clinical diagnosis of COPD (GOLD stage I to III): post-bronchodilator
FEV1/FVC ratio <0.70)
o Never smoker
o FEV1 reversibility <400 mL to rule out asthma
Severe COPD patients would be excluded as the process of sputum induction may
worsen their condition
ï?· History of lung condition other than COPD including respiratory infectious diseases
like tuberculosis, asthma, interstitial lung disease, etc
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mitochondrial respiration in PBMCs of healthy and COPD patientsTimepoint: 1
- Secondary Outcome Measures
Name Time Method oneTimepoint: 1