Serum AMH Levels in Patients Who Underwent Hypogastric Artery Ligation

Completed

• Conditions: AMH
• Interventions: Procedure: hypogastric artery ligation

• Registration Number: NCT03220594
• Lead Sponsor: Kanuni Sultan Suleyman Training and Research Hospital

Brief Summary

To observe the effects of hypogastric artery ligation on serum antimullerian hormone levels.

Detailed Description

To measure and compare serum antimullerian hormone levels in patients who underwent hypogastric artery ligation/ hypogastric artery ligation+ hysterectomy and postpartum control. The procedures performed as an emergency life saving method during delivery. The reasons for hypogastric artery ligation/ hypogastric artery ligation+ hysterectomy were obstetric hemorrhage mainly uterine atony.

The serum levels of antimullerian hormone were measured 6 months after the operations and compared with matching postpartum controls. Serum levels of FSH, LH, PRL and TSH were also measured 6 months after the operation. Further, antral follicle count measured along with the aforementioned blood tests.

Study Timeline

• Study Start: 2017-03-20
• Study First Submitted: 2017-07-14
• Study First Submitted QC: 2017-07-14
• Study First Posted: 2017-07-18
• Status Verified: 2017-09
• Primary Completion: 2017-09-20
• Study Completion: 2017-09-29
• Last Update Submitted: 2017-09-29
• Last Update Posted: 2017-10-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

• age 18- 40 years
• no systemic or endocrine diseases
• patients who had hypogastric artery ligation and/or hysterectomy
• healthy postpartum patients as controls

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Exclusion Criteria

• history of chemotherapy and/or radiotherapy
• Obese patients
• patients with previous/present endometriosis
• patients with PCOS

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
HAL and hysterectomy	hypogastric artery ligation	Patients who underwent both hypogastric artery ligation and hysterectomy performed during the delivery of their babies. Six months after the operation they will evaluated for their ovarian reserve via hormones and astral follicle count (AFC)
Hypogastric artery ligation (HAL)	hypogastric artery ligation	Patients who underwent only hypogastric artery ligation performed during the delivery of their babies. Six months after the operation they will evaluated for their ovarian reserve via hormones and astral follicle count (AFC)

Primary Outcome Measures

Name	Time	Method
Ovarian reserve	6 months	To evaluate postoperative ovarian reserve using anti-mullerian hormones and other ovary related hormones including FSH,LH

Trial Locations

Locations (1)

Kanuni SSTRH; 🇹🇷 İstanbul, Turkey