A CREDOS (Clinical Research Center for Dementia of South Korea) Study

Not Applicable

• Conditions: Diseases of the nervous system

• Registration Number: KCT0000353
• Lead Sponsor: Inha University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

1. Alzheimer's disease
1) Dementia by DSM-IV
2) Probable AD by NINCDS-ADRDA
3) Slowly progressive cognitive decline, at least for 6 months
2. Subcortical Vascular Dementia (SVD)
1) vascular dementia as described by the DSM-IV
2) has at least one focal neurologic sign
3) severe ischemic changes on brain MRI
3. MCI
1) No dementia or normal
2) Memory complaint by subject or study partner
3) Objective cognitive impairment
4) Preserved Activies Daily Living
4. vascular MCI
1) Compatible with the criteria of MCI
2) has at least one focal neurologic sign
3) severe ischemic changes on brain MRI
5.SMI
1) Subjective memory impairment
2) No objective memory impairment
3) Preserved Activies Daily Living
6. FTLD
FTLD by the Research criteria for frontotemporal dementia (Knopman et al. 2008)
1) Absence or insignificance of an anterograde amnesia and visuospatial impairment in the at least first 2 years of symptoms
2)Imaging demonstrating focal cerebral atrophy at least one of the following : the anterior temporal lobes, frontal lobes and insula or caudate nuclei

Exclusion Criteria

1) Blindness or hearing loss to be unable to be tested
2)sick-sinus syndrome, a second or third degree atrioventricular block
3)severe pulmonary disease (acute, severe, or unstable asthma, severe COPD)
4)an active gastric ulcer
5)uncontrolled diabetes mellitus
6)severe hepatic, or renal disease
7)uncured malignancy
8)major depressive disorder, psychosis
9)mental retardation
10)a history of encephalitis
11)head trauma with loss of consciousness longer than one hour
12)a brain tumor, a traumatic intracranial hemorrhage or a subarachnoid hemorrhage
13) abnormal TFT
14) a deficiency in vitamin B12 or folate
15) neurosyphilis
16)metabolic encephalopathy

Study & Design

• Study Type: Observational Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Progression of cognitive impairment

Secondary Outcome Measures

Name	Time	Method
conversion to dementia in MCI , conversion to MCI or dementia in SMI