The Lewy Body Study - an observational study that will assess the changes that occur in memory and thinking skills and changes that occur in the body of 100 participants with dementia with Lewy bodies over a 3 year period.

Not Applicable

Recruiting

• Conditions: dementia with Lewy bodies; Alzheimer's disease; Parkinson's disease dementia; Neurological - Dementias

• Registration Number: ACTRN12618000212257
• Lead Sponsor: Walter and Eliza Hall Institute of Medical Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-02-09
• Last Update Posted: 27 December 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

DLB/PDD/AD participants:
Fulfills clinical diagnostic criteria for probable dementia with Lewy bodies (DLB)
OR
Fulfills clinical diagnostic criteria for probable Parkinson's disease dementia (PDD)
OR
Fulfills clinical diagnostic criteria for probable Alzheimer's disease (AD)

AND:
Male or female aged 50+
MMSE greater than or equal to 14
no past history of alcohol or drug dependence
english as first language or adequate understanding for cognitive testing
adequate visual and auditory acuity to perform neuropsychological testing

Healthy Volunteers:
Male or female aged 50+
MMSE greater than or equal to 27
Absence of severe medical illness
No active, clinically significant psychiatric illness
No history of drug or alcohol dependence
English as first language or adequate understanding for cognitive testing
Adequate visual and auditory acuity to perform neuropsychological testing

Exclusion Criteria

DLB/PDD/AD participants:
alcohol intake greater than 4 standard alcoholic drinks per day
no identifiable family carer or other informant

Healthy controls:
No active, clinically significant psychiatric illness - this can impact on cognition and would not be suitable as a healthy control comparison
No severe medical illness that may impede study participation
contraindications to MRI (e.g. pacemaker, stents, metal implants)

Study & Design

• Study Type: Observational
• Study Design: Not specified