HIT in Insulin-resistant and Insulin-sensitive Obese Adolescents

Not Applicable

Completed

• Conditions: Insulin-resistant; Adolescents; Obesity
• Interventions: Other: Group Insulin-Resistant; Other: Group Insulin-Sensitive

• Registration Number: NCT03042234
• Lead Sponsor: Faculdade de Ciências Médicas da Santa Casa de São Paulo

Brief Summary

Evaluate the effects of HIT on the cardiorespiratory performance and substrate oxidation of insulin-resistant and insulin-sensitive obese adolescents.

Detailed Description

Objective: To evaluate the effect of high-intensity interval training (HIT) on the cardiorespiratory performance and substrate oxidation pattern in insulin-resistant and insulin-sensitive obese adolescents.

Study Timeline

• Study First Submitted: 2017-01-30
• Study First Submitted QC: 2017-02-01
• Study First Posted: 2017-02-03
• Study Start: 2017-07-08
• Primary Completion: 2017-08-30
• Study Completion: 2018-11-02
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-11
• Last Update Posted: 2021-07-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• aged 12-16 years
• with a body mass index z-score (zBMI) ≥ + 2SD
• puberty stage > 3
• the boys and girls had to present a minimum physical fitness, according to the International Physical Activity Questionnaire (IPAQ), according to the activity performed during the last week and confirmed this using the peak cardiopulmonary test (VO2).

Exclusion Criteria

• individuals undergoing drug treatment for weight control;
• indiviudals who had cardiac, orthopedic, respiratory or renal problems, diabetes, uncontrolled hypertension, genetic syndrome or hormonal abnormalities.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group Insulin-sensitive	Group Insulin-Sensitive	Insulin-sensitive obese adolescents
Group Insulin-resistant	Group Insulin-Sensitive	Insulin-resistant obese adolescents
Group Insulin-resistant	Group Insulin-Resistant	Insulin-resistant obese adolescents
Group Insulin-sensitive	Group Insulin-Resistant	Insulin-sensitive obese adolescents

Primary Outcome Measures

Name	Time	Method
rate of Intensity at first ventilatory anaerobic threshold (VAT1)	4 weeks	The cardiopulmonary test protocol included running on a treadmill (Model ATL, Inbrasport Ltda; Brazil) at a speed of 4 km/h with 1 km/h increments every minute until the participant showed exhaustion.; We evaluated ventilatory parameters on a gas analyzer (model VO2000; Inbrasport Ltda; Brazil).We determined VAT1 (ml/kg/min) using the V-slope method of Beaver et al.
rate of Peak Heart rate	4 weeks	The cardiopulmonary test protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil). speed of 4 km / h with increments of 1 km / h every minute until the participant shows exhaustion.
rate of carbohydrate oxidation	4 weeks	The substrate oxidation pattern protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil),during continuous exercise of submaximal intensity (45 minutes of treadmill running at the intensity of the first ventilatory anaerobic threshold).
rate of Peak oxygen consumption (VOpeak)	4 weeks	The cardiopulmonary test protocol for determination the VOpeak (ml/kg/min) included running on a treadmill (Model ATL, Inbrasport Ltda; Brazil) at a speed of 4 km/h with 1 km/h increments every minute until the participant showed exhaustion.; We evaluated ventilatory parameters on a gas analyzer (model VO2000; Inbrasport Ltda; Brazil).
rate of lipid oxidation	4 weeks	The substrate oxidation pattern protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil),during continuous exercise of submaximal intensity (45 minutes of treadmill running at the intensity of the first ventilatory anaerobic threshold).

Trial Locations

Locations (3)

Emef Plinio Queroz; 🇧🇷 São Paulo, Brazil

Emef Angelina Maffei Vita; 🇧🇷 Sao Paulo, Brazil

Santa Casa of Sao Paulo School; 🇧🇷 Sao Paulo, Brazil