A randomized study to compare the effect of low-dose Ketamine versus Fentanyl on the hemodynamic response to laryngoscopy and endotracheal intubation in Department of Anaesthesiology, SMS Medical College and Attached Hospitals, Jaipur .
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Hypertension
研究概览
简要总结
This study is a randomised double blinded comparative study between Low dose Ketamine (0.5mg/kg) and Fentanyl in attenuating hemodynamic response to laryngoscopy and endotracheal intubation in 66 patients undergoing surgeries under General Anaesthesia. The primary outcomes are systemic blood pressure, diastolic blood pressure, mean arterial pressure, and mean heart rate at different time points like before laryngoscopy, during induction, during laryngoscopy and after laryngoscopy at 2 minutes intervals for 10 minutes and nothing side effects if any.
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Elective Surgery under General Anaesthesia Patient willing to give informed and written consent Age group between 18-50 ASA grade 1&2.
排除标准
- •History of allergy or contraindications of any study drug
- •Patients scheduled for emergency surgery
- •Hypertension.
- •known or previously dignosed
- •Dementia or psychiatric illness
- •Known Ischemic heart disease
- •Raised intracranial pressure or intracranial pathology where a rise in intracranial pressure would pose a risk or patients scheduled for neurosurgical procedures
- •History or indicator of or proven difficult ventilation or laryngoscopy or intubation Intubation time more than 30 seconds or repeated attempts at intubation 9.
结局指标
主要结局
Hypertension
时间窗: At baseline when patient comes to Operation theatre, post induction- within 1 minute of giving induction agent, during laryngoscopy, just after intubation and at 2, 4, 6, 8,10 minutes interval after intubation
次要结局
- Tachycardia , post induction hypotension & any side effects(At baseline, post induction, during laryngoscopy, just after intubation & for 10 minutes at 2 minutes interval)
研究者
Trishala Jain
SMS Medical College