NCT05930600
Completed
Not Applicable
Internal Jugular Venous Distensibility Index and Innominate Venous Flow Patterns As Predictors of Response to Fluid Administration in Elective Surgery Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Fluid Responsiveness
- Sponsor
- Indonesia University
- Enrollment
- 79
- Locations
- 1
- Primary Endpoint
- IJV distensibility index correlation to fluid responsiveness
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The measurement of internal jugular vein distensibility index corresponds to the measurement of stroke volume using trans-thoracic Doppler echocardiography in assessing the response to fluid administration in elective surgical patients.
Investigators
Dita Aditianingsih
Principal investigator, MD, PhD, Anesthesiologist Consultant
Indonesia University
Eligibility Criteria
Inclusion Criteria
- •Utilizing intraoperative mechanical ventilation with a tidal volume of 8 ml/kg (PBW).
- •ASA physical status 1-
- •Mongoloid ethnicity.
- •Willing to participate in the research and sign the informed consent.
Exclusion Criteria
- •Patients with symptoms and signs of fluid overload, such as pulmonary edema, pleural effusion, ascites, and peripheral edema.
- •Patients with chronic or acute kidney dysfunction, renal replacement therapy history, and/or oliguria (urine output \<0.5 ml/kg/hour).
- •Patients with cardiovascular diseases, including heart failure, cardiac arrhythmias, moderate-to-severe valvular abnormalities, a history of angina/myocardial infarction, pulmonary hypertension, and peripheral artery disease.
- •Patients with anatomical abnormalities in the neck and chest region that make it impractical to perform jugular vein ultrasound and transthoracic echocardiography.
- •Jugular vein thrombosis.
- •Superior vena cava syndrome.
- •Placement of jugular vein catheter.
- •Body mass index (BMI) greater than 30.0 kg/m
- •Patients with contraindications to the use of muscle relaxants.
- •Patients with lung hyperinflation and pleural effusion.
Outcomes
Primary Outcomes
IJV distensibility index correlation to fluid responsiveness
Time Frame: 1 day
Correlation between IJV distensibility index and fluid responsiveness defined as increase of stroke volume more than 10% after fluid challenge
Secondary Outcomes
- Innominate vein flow velocity correlation to fluid responsiveness(1 day)
- Comparison of IJV distensibility index in fluid responders and non-fluid responders.(1 day)
- Detection of sensitivity, specificity, positive predictive value, negative predictive value, and best cut off value of IJV distensibility index to predict fluid responsiveness(1 day)
- Correlation of IJV distensibility index and stroke volume(1 day)
Study Sites (1)
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