Phase Contrast Imaging used for a quantitative evaluation of myocardial contractility in left ventricular dilatation and for the detection of myocardial ischemia

Recruiting

• Conditions: Diseases of the circulation system; I20-I25; Ischaemic heart diseases

• Registration Number: DRKS00000015
• Lead Sponsor: niversitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-09-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Part 1:
Patients with LVEDD>55 mm:
20 patients with dilatative cardiomyopathy
20 patients with relevant mitral- oder aortic insufficiency
20 patients with arterial hypertension or aortic stenosis
Part 2:
20 patients with suspected CAD
Part 3:
20 patients with acute myocardial infarction

Amendment:
1. 60 additional healthy volunteers
2. 20 patients with complete left bundle branch block without cardiac disease and normal LVEF
3. 50 patients mit with complete left bundle branch block, LVEF=35%, LVEDD > 55 mm and heart failure (NYHA class = II) with dilated cardiomyopathy before CRT
4. 80 patients after heart transplantation (also follow-up)

Exclusion Criteria

Part 1:
CAD, contraindications against MRI
Part 2:
Contraindications against MRI, Gadolinium or Adenosin. Reduced left ventricular function, relevant valvular disease, left bundle branch block.
Part 3:
Contraindications against MRI, Gadolinium or Adenosin. Reduced left ventricular function, relevant valvular disease, left bundle branch block.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences/changes of myocardial motion

Secondary Outcome Measures

Name	Time	Method
in patients after HTX or CRT: changes of clinical parameters (NYHA classes etc.)