Acute effects of electronic cigarette on lung function and airway inflammation in patients with asthma

Not Applicable

Completed

• Conditions: Asthma; Respiratory

• Registration Number: ISRCTN89151172
• Lead Sponsor: Pulmonary Clinic and Respiratory Failure Unit of Aristotle University of Thessaloniki, General Hospital of Thessaloniki ''Georgios Papanikolaou''

Brief Summary

2020 results in https://pubmed.ncbi.nlm.nih.gov/32239706 (added 07/04/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-05-30
• Study Start: 2018-08-08
• Last Update Posted: 27 April 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Asthma patients:
1. Every-day smoker:
1.1. Smoked at least 100 cigarettes in their lifetime
1.2. Smoke every day at the time of research
2. Moderate asthma
3. Aged over 18 years old

Healthy controls:
1. Every-day smoker:
1.1. Smoked at least 100 cigarettes in their lifetime
1.2. Smoke every day at the time of research
2. Visited the smoking cessation clinic or other pulmonary dispensaries of the hospital during the research
3. Aged over 18 years old
Healthy controls were matched with asthma patients on baseline characteristics including age, gender, height, weight, BMI and number of pack-years.

Exclusion Criteria

For the group of asthma patients:
1. Mild or severe asthma and not receiving therapy of step 3 according to 2016 GINA guidelines
2. Any chronic disease other than asthma
3. Acute asthma exacerbation the last month before the study
4. Use of corticosteroids
5. Any acute disease 2 weeks prior to the study.
6. Use of any medication except for asthma treatment currently or in the 2 weeks prior to study participation
7. Having smoked since their morning awakening and/or had an Exhaled CO measurement of over 5 ppm the day they would take part in the study

For the control group:
1. Any chronic disease
2. Any acute disease currently or in the 2 weeks prior to study participation
3. Having smoked since their morning awakening and/or had an Exhaled CO measurement of over 5 ppm the day they would take part in the study

Study & Design

• Study Type: Other
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in the Fraction of Exhaled Nitric Oxide (FENO) before and after the use of the e-cigarette in patients with asthma, compared to changes at the same timepoints in healthy controls. Participants underwent FENO measurements, and then were asked to smoke an e-cigarette for 5 minutes. After 30 minutes, participants underwent another FENO measurement. FENO measurements were performed using the Denox 88 ECOMEDICS.