NCT01600768Unknown不适用
Evaluation of Extended Intravenous of Beta-lactams in the Treatment of Serious Gram-negative Infections in Critically Ill Patients
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- serum concentrations of beta-lactams
研究概览
简要总结
The purpose of this study is to evaluate the PK/PD parameters, safety and efficacy of extended infusion of beta-lactams in intensive care patients who are infected with Gram-negative bacteremia or pneumonia at National Taiwan University Hospital (NTUH).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (> 18 years)
- •Admitted on the intensive care unit
- •Starting a treatment with beta-lactams antibiotics
- •Signed informed consent
- •Expected to live > 3 days
排除标准
- •renal insufficiency (estimated clearance < 20 ML /MIN)
- •renal replacement therapy
- •ANC < 1000 103 µl
- •pregnancy
- •drug abuse
研究组 & 干预措施
intermittent infusion
Active Comparator
干预措施: Beta-Lactams (Drug)
extended infusion
Experimental
干预措施: Beta-Lactams (Drug)
结局指标
主要结局
serum concentrations of beta-lactams
时间窗: 6 hours
Determination of serum concentrations of beta-lactams
次要结局
未报告次要终点
研究者
研究点 (1)
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