The Influence of High Impact Exercise on Musculoskeletal Health in Older Men

Not Applicable

Completed

• Conditions: Bone Strength; Neuromuscular Function
• Interventions: Behavioral: Exercise

• Registration Number: NCT02007460
• Lead Sponsor: Loughborough University

Brief Summary

Osteoporotic fractures are an extremely common and serious public health issue which contribute substantially to pain, impaired mobility and morbidity in the elderly. Declines in bone strength combined with an increase risk of falls (associated with decline in muscular function with age) are the main determinants of fracture risk. Exercise that is novel and involves impact loading has the potential to improve bone strength and neuromuscular function (strength, power and balance). It is thus imperative to evaluate potential benefits of exercise in older people. The musculoskeletal responses to exercise may also be influenced by vitamin D status. It is the purpose of this study to consider the influence of a one year unilateral (one limb) high impact exercise programme on musculoskeletal health, specifically bone structure, muscle strength and power in older caucasian men. It is also the purpose of this study to determine whether this differs according to vitamin D status. The findings will reveal whether exercise can improve bone health and/or neuromuscular function, and whether improvements are dependent upon vitamin D status.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2012-01
• Study Completion: 2012-01
• Study First Submitted: 2013-11-27
• Status Verified: 2013-12
• Study First Submitted QC: 2013-12-05
• Last Update Submitted: 2013-12-05
• Study First Posted: 2013-12-10
• Last Update Posted: 2013-12-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

• Healthy community dwelling men of white european origin

Exclusion Criteria

• BMI >30 kg/m2
• History of strength training or recently ( previous 12 months) doing moderate physical activity (weight bearing, high impact)
• Recent ( previous 12 months) or current medical or surgical problems likely to affect bone metabolism or provide contraindications to high impact exercise, balance or neuromuscular function
• Any previous or existing lower back or limb problems that could be exacerbated by undertaking high impact exercise
• Any history of diagnosed or symptomatic diseases likely to influence strength, power, bone or habitual activity (including osteomalacia or impaired liver/renal function and locomotor disease, hypertension) that influences bone or muscle or precludes exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Exercise leg	Exercise	-

Primary Outcome Measures

Name	Time	Method
Change in femoral neck bone mineral density	baseline, 12 months

Secondary Outcome Measures

Name	Time	Method
Change in trabecular bone mineral content	baseline, 12 months
Change in electromyography of quadriceps during hopping	baseline, 6 months
Change in postural sway amplitude (mm)	baseline, 6 months
Change in cortical bone mineral content	baseline, 12 months
Change in ground reaction force during hopping	baseline, 6 months, 12 months
Change in leg press strength	baseline, 6 months
Change in maximal isometric knee extensor strength	baseline, 6 months
Change in tendon stiffness	baseline, 6 months

Trial Locations

Locations (1)

Loughborough University; 🇬🇧 Loughborough, Leicestershire, United Kingdom