The Use of Propranolol for the Prevention of Worsening of Esophageal Varices in Patients With Isolated Gastric Varices

Not Applicable

• Conditions: Liver Cirrhoses; Portal Hypertension; Gastric Varix
• Interventions: Drug: Propranolol

• Registration Number: NCT03171805
• Lead Sponsor: West China Hospital

Brief Summary

Balloon-occluded retrograde transvenous obliteration (BRTO) has been effective method to manage gastric varices. However, more than one third of patients after BRTO treatment experienced worsening of esophageal varices. The present study was designed to evaluate the effect of post-BRTO propranolol adminstration on the change of esophageal varices.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-05-26
• Study First Submitted QC: 2017-05-26
• Study First Posted: 2017-05-31
• Study Start: 2017-06-01
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-20
• Last Update Posted: 2021-11-23
• Primary Completion: 2022-05-15
• Study Completion: 2022-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

1. Clinical diagnosis of liver cirrhosis
2. Clinical diagnosis of isolated gastric varices
3. The presenec of spontaneous portosystemic shunt

Exclusion Criteria

1. Contradictions to Propranolol
2. Balloon occluded retrograde transvenous obliteration was failed

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Propranolol group	Propranolol	Propranolol was given after patients with cirrhosis and isolated gastric varices underwent balloon occluded retrograde transvenous obliteration successfully.

Primary Outcome Measures

Name	Time	Method
Worsening of esophageal varices rate	3 years	Analysis

Secondary Outcome Measures

Name	Time	Method
Mortality rate	3 years	Analysis
Worsening of ascites rate	3 years	Analysis
Variceal rebleeding rate	3 years	Analysis

Trial Locations

Locations (1)

West china Hospital; 🇨🇳 Chengdu, China