1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia
- Registration Number
- NCT03510013
- Lead Sponsor
- Khon Kaen University
- Brief Summary
The investigators propose a new wash-in technique for sevoflurane low flow anesthesia with fresh gas flow of O2:N2O or O2:air 1:1 L/min with sevoflurane 8%.
The objective of this study is to identify time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5%
- Detailed Description
The benefits of low flow anesthesia are economic, less pollution, more heat and humidity preservation but it requires appropriate wash-in phase. The current wash-in protocols for sevoflurane are complicated and time consuming. The investigators propose a new 1-1-8 sevoflurane wash-in protocol which is more simple and predictable.
The objective of this study is to identify time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5% with 1-1-8 wash-in protocol.
All patients will receive iv propofol 2 mg/kg as induction agent and succinyl choline 1.5 mg/kg for intubation. Then the ventilation will be controlled to achieve end-tidal CO2 30-35 mmHg with O2:N2O or O2:air 1:1 L/min with sevoflurane 8%. Time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5% will be recorded and analyzed. After that, the concentration of sevoflurane and anesthetic technique will be adjusted to requirement of anesthesiologist.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- ASA classification I-II
- age 18-65 years
- BMI > 35
- contraindicated for N2O
- • with pulmonary or cardiac disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1-1-8 wash-in 1-1-8 wash-in Wash-in using O2:N2O or O2:air 1:1 L/min with sevoflurane 8% 1-1-8 wash-in Sevoflurane Wash-in using O2:N2O or O2:air 1:1 L/min with sevoflurane 8%
- Primary Outcome Measures
Name Time Method Time participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes Time (in second) to achieve alveolar concentration of sevoflurane 1, 1.5, 2, 2.5, 3, and 3.5%
- Secondary Outcome Measures
Name Time Method Heart rate participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes] Heart rate (beat/min) at alveolar concentration of sevoflurane of 1, 1.5, 2, 2.5, 3 and 3.5%
Blood pressure participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes] Blood pressure (systolic and diastolic (mmHg)) at alveolar concentration of sevoflurane of 1, 1.5, 2, 2.5, 3 and 3.5%
Trial Locations
- Locations (1)
Faculty of Medicine, Khon Kaen University
🇹🇭Khon Kaen, Thailand