1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Time
研究概览
简要总结
The investigators propose a new wash-in technique for sevoflurane low flow anesthesia with fresh gas flow of O2:N2O or O2:air 1:1 L/min with sevoflurane 8%.
The objective of this study is to identify time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5%
详细描述
The benefits of low flow anesthesia are economic, less pollution, more heat and humidity preservation but it requires appropriate wash-in phase. The current wash-in protocols for sevoflurane are complicated and time consuming. The investigators propose a new 1-1-8 sevoflurane wash-in protocol which is more simple and predictable.
The objective of this study is to identify time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5% with 1-1-8 wash-in protocol.
All patients will receive iv propofol 2 mg/kg as induction agent and succinyl choline 1.5 mg/kg for intubation. Then the ventilation will be controlled to achieve end-tidal CO2 30-35 mmHg with O2:N2O or O2:air 1:1 L/min with sevoflurane 8%. Time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5% will be recorded and analyzed. After that, the concentration of sevoflurane and anesthetic technique will be adjusted to requirement of anesthesiologist.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASA classification I-II
- •age 18-65 years
排除标准
- •BMI > 35
- •contraindicated for N2O
- •• with pulmonary or cardiac disease
研究组 & 干预措施
1-1-8 wash-in
Wash-in using O2:N2O or O2:air 1:1 L/min with sevoflurane 8%
干预措施: 1-1-8 wash-in (Procedure)
1-1-8 wash-in
Wash-in using O2:N2O or O2:air 1:1 L/min with sevoflurane 8%
干预措施: Sevoflurane (Drug)
结局指标
主要结局
Time
时间窗: participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes
Time (in second) to achieve alveolar concentration of sevoflurane 1, 1.5, 2, 2.5, 3, and 3.5%
次要结局
- Heart rate(participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes])
- Blood pressure(participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes])
研究者
Thepakorn Sathitkarnmanee
Associate Professor
Khon Kaen University