Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery and Anesthetic Depth

Phase 4

• Conditions: Anesthesia
• Interventions: Procedure: Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Desflurane; Procedure: Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Sevoflurane

• Registration Number: NCT05024084
• Lead Sponsor: Ufuk University

Brief Summary

Minimal flow anesthesia has economic and environmental advantages in addition to providing earlier recovery following general anesthesia. There is a paucity of data concerning the effect of minimal flow anesthesia (fresh gas flow \<0,5 l/min) on recovery parameters. The primary objective of this study is to compare the recovery parameters of desflurane and sevoflurane in minimal flow anesthesia while the secondary objective is to compare the effect of these agents on anesthetic depth using bispectral index.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-08-13
• Study First Submitted QC: 2021-08-26
• Study First Posted: 2021-08-27
• Status Verified: 2021-09
• Study Start: 2021-09-05
• Last Update Submitted: 2021-09-17
• Last Update Posted: 2021-09-20
• Primary Completion: 2021-10-01
• Study Completion: 2021-10-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

• Ages between 18 and 65
• Patients undergoing elective surgery under general anesthesia
• Patients with an American Society of Anesthesiologists Classification I or II

Exclusion Criteria

• Patient refusal
• Emergency surgery
• Patients with a contraindication for minimal flow anesthesia
• Uncontrolled diabetes mellitus
• History of serious systemic disease (cardiac, pulmonary, hepatic)
• Utilization of another analgesic technique such as central or peripheral nerve blocks

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group Desflurane	Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Desflurane	The patients in this arm will be given Desflurane (7-8%) as volatile anesthetic throughout the duration of anesthesia.
Group Sevoflurane	Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Sevoflurane	The patients in this arm will be given Sevoflurane (2-3%) as volatile anesthetic throughout the duration of anesthesia.

Primary Outcome Measures

Name	Time	Method
Time until transfer readiness	Up to 45 minutes after discontinuation of the volatile anesthetic	Time interval between discontinuation of the volatile anesthetics and Aldrete score reaching 9 or greater
Time until extubation	Up to 10 minutes after discontinuation of the volatile anesthetic	Time interval between discontinuation of the volatile anesthetics and removal of the endotracheal tube
Time until eye opening	Up to 20 minutes after discontinuation of the volatile anesthetic	Time interval between discontinuation of the volatile anesthetics and eye opening with verbal command

Secondary Outcome Measures

Name	Time	Method
Anesthetic depth provided by the volatile anesthetic	Change in Bispectral Index values at 5, 10, 15, 30, 60 and 120 minutes	Anesthetic depth as measured by Bispectral Index

Trial Locations

Locations (1)

Ufuk University Dr. Rıdvan Ege Hospital; 🇹🇷 Ankara, Turkey