Plaque Stability and Metabolomics in Coronary Heart Disease

• Conditions: Coronary Artery Disease

• Registration Number: NCT05270330
• Lead Sponsor: Shaanxi Provincial People's Hospital

Brief Summary

At present, the investigators don't know the relationship between plaque stability and the metabonomics changes. In the present study, investigators will evaluate the plaque stability by intravascular unltrasound in stable coronary heart patients, and metabonomics was also assessed by high throughput sequencing. Statistic analysis were carried out to analyze the correlation between plaque stability and metabonomics changes among these study patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-01
• Study First Submitted: 2022-01-22
• Status Verified: 2022-03
• Study First Submitted QC: 2022-03-06
• Last Update Submitted: 2022-03-06
• Study First Posted: 2022-03-08
• Last Update Posted: 2022-03-08
• Primary Completion: 2024-07-31
• Study Completion: 2024-07-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients who diagnosed with stable coronary heart disease and evaluated for plaque stability by IVUS will be recruited.

Exclusion Criteria

• renal insufficiency with serum creatinine > 20 mg/L;
• regnant/lactating women, or the women receive hormone replacement therapy in premenopausal or postmenopausal;
• patients have a history of abusing alcohol or other drugs in the past two years, active hepatitis, cirrhosis;
• endocrine abnormalities without therapy (diabetic ketoacidosis, thyroid disease, etc.);
• The body's inflammatory disease, rheumatoid arthritis, osteoarthritis, ulcerative bowel disease, systemic lupus erythematosus (sle), etc.), myositis/myopathy, cancer;
• Dilated cardiomyopathy, valvular heart disease, persistent atrial fibrillation;
• patients recently injured;（8）Other researchers don't agree to join this study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plaque stability	07/01/2021-07/31/2024	The investigators will use the intravascular ultrasound to assess the coronary plaque stability of the patients with coronary heart disease.

Secondary Outcome Measures

Name	Time	Method
Metabonomics	07/01/2021-07/31/2024	Serum or plasma will be collected by the investigators and high-throughput sequencing will be used to assess the metabonomics of patients with coronary heart disease.

Trial Locations

Locations (1)

Shaanxi Provincial People's Hospital; 🇨🇳 Xi'an, Shaanxi, China