NCT05270330Unknown不适用
The Relationship Between Plaque Stability Evaluated by IVUS and Metabolomics in Stable Coronary Heart Disease Patients
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Plaque stability
研究概览
简要总结
At present, the investigators don't know the relationship between plaque stability and the metabonomics changes. In the present study, investigators will evaluate the plaque stability by intravascular unltrasound in stable coronary heart patients, and metabonomics was also assessed by high throughput sequencing. Statistic analysis were carried out to analyze the correlation between plaque stability and metabonomics changes among these study patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who diagnosed with stable coronary heart disease and evaluated for plaque stability by IVUS will be recruited.
排除标准
- •renal insufficiency with serum creatinine > 20 mg/L;
- •regnant/lactating women, or the women receive hormone replacement therapy in premenopausal or postmenopausal;
- •patients have a history of abusing alcohol or other drugs in the past two years, active hepatitis, cirrhosis;
- •endocrine abnormalities without therapy (diabetic ketoacidosis, thyroid disease, etc.);
- •The body's inflammatory disease, rheumatoid arthritis, osteoarthritis, ulcerative bowel disease, systemic lupus erythematosus (sle), etc.), myositis/myopathy, cancer;
- •Dilated cardiomyopathy, valvular heart disease, persistent atrial fibrillation;
- •patients recently injured;（8）Other researchers don't agree to join this study.
结局指标
主要结局
Plaque stability
时间窗: 07/01/2021-07/31/2024
The investigators will use the intravascular ultrasound to assess the coronary plaque stability of the patients with coronary heart disease.
次要结局
- Metabonomics(07/01/2021-07/31/2024)
研究者
Liu Zhongwei
Professor
Shaanxi Provincial People's Hospital
研究点 (1)
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