Modulation of gastric function and protein assimilation by different proteins sources in enteral nutrition formulas.
Completed
- Conditions
- Healthy volunteers
- Registration Number
- NL-OMON29207
- Lead Sponsor
- Danone Research – Centre for Specialised Nutrition
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. Healthy subjects (male/female);
2. Age between 18 and 50;
Exclusion Criteria
1. History of gastrointestinal, cardiorespiratory (including arterial hypertension), hematologic, renal, atopic, alimentary or psychiatric disorder, panic attacks, diabetes, drug or alcohol abuse;
2. Anemia (Hb < 7.5 mmol/l);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary parameter in this study is gastric emptying time derived from a mathematical gastric emptying model (MRI).
- Secondary Outcome Measures
Name Time Method 1. Gastric emptying time measured with 13C breath test;<br /><br>2. Changes in postprandial plasma amino acid profile;<br /><br>3. Volume and dynamics of gastric secretions;<br /><br>4. Intragastric distribution and macrostructural changes of the meal;<br /><br>5. Gastrointestinal symptoms (heartburn, satiety, belching, nausea, vomiting, abdominal distension);<br /><br>6. Changes in postprandial plasma glucose profiles.