Effects of local oestrogen on vaginal microcirculation in the treatment of vaginal atrophy

Completed

• Conditions: Vaginal atrophy; 10047789

• Registration Number: NL-OMON41036
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Women with vaginal atrophy diagnosed based on:
a. The presence of one or more of the following symptoms:
- Vaginal dryness
- Vaginal itching/irritation
- Dyspareunia
b. The presence of one or more of the following symptoms on physical examination:
- Presence of vaginal wall pallor and petechiae
- Friability of the vaginal wall (defined as any bleeding occurring during examination)
- Conization (markedly decreased elasticity)
- Absence of rugae

Exclusion Criteria

1. Previous pelvic surgery
2. Cardiovascular disease (e.g. angina pectoris, hypertension)
3. Inflammatory disease (e.g. rheumatoid arthritis, eczema)
4. Other systemic illness (e.g. (non-) insulin dependent diabetes mellitus)
5. Medications (e.g. anticoagulants, anti-inflammatory, or immunosuppressive agents) that could influence the microcirculation

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences in measurements of microcirculatory parameters in patients with VA<br /><br>and before and after treatment with local oestrogen.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n/a</p><br>