The Effect of Remote Ischemic Postconditioning on Postoperative Renal Dysfunction in Patients Undergoing Valvular Heart Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 252
- 试验地点
- 1
- 主要终点
- incidence of postoperative renal dysfunction using AKIN(acute kidney injury network) criteria
研究概览
简要总结
Ischemic reperfusion injury of cardiopulmonary bypass and postoperative renal dysfunction is a common problem which influence poor outcome in subjects undergoing valvular heart surgery. The incidence of postoperative renal dysfunction was reported as high as 7~8% in heart surgery using bypass, and is thought to be caused by ischemia/reperfusion injury. Remote ischemic postconditioning was also reported to be protective for ischemic/reperfusion injury in previous animal studies and stoke patients. Therefore, the investigators are trying to evaluate the clinical effect of remote ischemic postconditioning on postoperative renal dysfunction in subjects undergoing valvular heart surgery with bypass.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who are undergoing valvular heart surgery
- •age 19-80
排除标准
- •peripheral vascular disease with circulation deterioration
- •Renal replacement therapy
- •preconditioning medication
- •Myocardiac infarction within 3 weeks
- •active infective endocarditis
- •high dosage steroid therapy
- •mental retardation
- •unlettered person
研究组 & 干预措施
post-ischemic conditioning group
干预措施: remote ischemic postconditioning (Procedure)
valvular surgery with bypass group
干预措施: valvular surgery with bypass (Procedure)
结局指标
主要结局
incidence of postoperative renal dysfunction using AKIN(acute kidney injury network) criteria
时间窗: 5 days
次要结局
未报告次要终点