Impact of Neuropsychological Alteration of Decision-making Abilities on the Functioning of Patients With Eating Disorders

Not Applicable

• Conditions: Eating Disorder
• Interventions: Behavioral: Ambulatory cares in a day-hospital (University Hospital of Montpellier) specialized in the evaluation of eating disorders

• Registration Number: NCT03160443
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

Eating disorders are multifactorial disorders currently conceptualized in a biopsychosocial model, but pathophysiology remains relatively unknown, and robust etiological models to guide treatment are therefore lacking. Different endophenotypes and neurocognitive vulnerability factors have been found in eating disorders including decision making abnormalities. The investigators hypothesize that decision making abnormalities are associated with a lower level of functioning and quality of life which could lead to social and interpersonal difficulties. The investigators also hypothesize that these anomalies are associated with a particular clinical profile (more restrictive profile, more hyperactivity, less insight on the disease and desire for care ...).

Detailed Description

The investigators will recruit a total of 340 patients with an eating disorder in the university hospital of Montpellier.

* Participation consists of a one-day visit with a multidisciplinary assessment. No action is specific to research. This is the usual management of patients with eating disorders addressed to our department.

* An ancillary study will be proposed, if the patient is addressed by his general practitioner for an annual evaluation. This second visit will be exactly the same as the initial visit.

Study Timeline

• Study Start: 2017-05-03
• Study First Submitted: 2017-05-11
• Study First Submitted QC: 2017-05-18
• Study First Posted: 2017-05-19
• Status Verified: 2021-12
• Last Update Submitted: 2021-12-20
• Last Update Posted: 2021-12-21
• Primary Completion: 2022-07-30
• Study Completion: 2022-07-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 340

Inclusion Criteria

• Patient with an eating disorder according to Diagnostic and Statistical Manuel of Mental disorders-V (DSM-V) criteria
• Patient aged from 15 to 65 years
• Patient who performs the day-hospital evaluation
• Patient affiliated to a French social security system
• Patient able to understand the nature, the aim and the methodology of the study
• For minor one of the legal guardians gave his consent

Exclusion Criteria

• Patient in an unstable somatic state (eg severe metabolic disorder making impossible or unreliable neuropsychological assessments)
• Patient's refusal to participate
• Patient on protective measures (guardianship or trusteeship)
• Pregnant or nursing women. A dosage of beta human chorionic gonadotropin (βHCG) will be performed to ensure the absence of pregnancy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Participants	Ambulatory cares in a day-hospital (University Hospital of Montpellier) specialized in the evaluation of eating disorders	All participants performed the same evaluation: clinical and neuropsychological assessment. All of them are patients with an eating disorder.

Primary Outcome Measures

Name	Time	Method
Level of functional impairment assessed by the Work and Social Adjustment Scale (WSAS)	Baseline	We aim to investigate the link between decision-making and daily functioning of patients with eating disorder.

Secondary Outcome Measures

Name	Time	Method
Level of functional impairment assessed by the clinician with the Functional Assessment Staging Test (FAST) scale	Baseline	We aim to investigate the link between global functioning and alteration of cognitive flexibility of patients with eating disorder.
Quality of life assessed by the Eating disorder quality of life (EDQOL) scale.	Baseline	We aim to investigate the link between quality of life and alteration central coherence of patients with eating disorder.
Level of functional impairment assessed by the clinician with the FAST scale	Baseline	We aim to investigate the link between global functioning and alteration central coherence of patients with eating disorder.
Score to decision making test (Iowa gambling task)	At 12 months if patient is included in the ancillary study	We aim to investigate the impact of weight recovery on decision making abilities

Trial Locations

Locations (1)

Hôpital Lapeyronie; 🇫🇷 Montpellier, France