ung Ultrasound Score and its predictability for need of surfactant and grade of severity of respiratory distress syndrome in premature neonates -a Cohort study Study
Not Applicable
- Conditions
- Health Condition 1: P220- Respiratory distress syndrome of newborn
- Registration Number
- CTRI/2021/09/036770
- Lead Sponsor
- Manish Swami
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All babies <=32 weeks/ <=1250gms with respiratory distress within first 2 hours of life irrespective of type respiratory support or requirement of resuscitation needed at birth.
Exclusion Criteria
1.Neonates with hemodynamic instabilities (severe sepsis/ refractory shock).
2.Neonates with antenatally detected intrathoracic malformations including congenital heart defects
3.Neonates with other associated respiratory morbidities (air-leaks, MAS, pulmonary haemorrhage)
4.Babies admitted to the NICU after administration of surfactant in the delivery room
5.Consent/ Assent not given by parents
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.POCUS Lung score will be assessed in 6 predefined areas of lung fields, Within 2 hours after birth and before administration of surfactant. <br/ ><br>2.Requirement of surfactant-when baby on Nasal Continuous Positive Airway Pressure (NCPAP) 5 cm of water with FIO2 requirement â?¥0.30 (â?¤26 weeks), or â?¥0.40 (26 weeks) with target SpO2 of 91% â?? 95% (after 10 min of life) <br/ ><br>Timepoint: 1.POCUS Lung score will be assessed in 6 predefined areas of lung fields, Within 2 hours after birth and before administration of surfactant. <br/ ><br>2.Requirement of surfactant-when baby on Nasal Continuous Positive Airway Pressure (NCPAP) 5 cm of water with FIO2 requirement â?¥0.30 (â?¤26 weeks), or â?¥0.40 (26 weeks) with target SpO2 of 91% â?? 95% (after 10 min of life) <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.Oxygenation status-Oxygenation Index (OI),a/A ratio, S/F ratio,PaO2. <br/ ><br>2.Nasal CPAP failure and need for invasive mechanical ventilation within the first 72 hours after birth. <br/ ><br>3.Severity of RDS on Chest Xray. <br/ ><br>4.Severity of RDS based on clinical parameters (Silverman-Andersen score). <br/ ><br> <br/ ><br> <br/ ><br>Timepoint: 1.Oxygenation status-Oxygenation Index (OI),a/A ratio, S/F ratio,PaO2- with in 30 mins of lung ultrasound <br/ ><br>2.Nasal CPAP failure and need for invasive mechanical ventilation within the first 72 hours after birth. <br/ ><br>3.Severity of RDS on Chest Xray-with in 30 mins of lung ultrasound <br/ ><br>4.Severity of RDS based on clinical parameters (Silverman-Andersen score)-with in 30 mins of lung ultrasound