Pain on movement while performing weight-bearing and non-weight-bearing activities in patients with knee osteoarthritis

Completed

Lead Sponsor: Manipal College of Health Professions, Manipal Academy of Higher Education

Brief Summary: After CTRI approval has been obtained, the participants will be screened based on the inclusion and exclusion criteria. They will be included in the study after giving their informed consent. Demographic details and knee osteoarthritis characteristics will be recorded, after which Knee Injury and Osteoarthritis Outcome Score (KOOS) and Michigan Body Map (MBM) will be administered. The participants will be asked to perform weight-bearing and non-weight-bearing activities, during which the movement evoked pain and its sensitivity will be recorded using the 11-point Numeric Rating Scale (NPRS). Quantitative sensory tests (QST)- temporal summation and pain pressure threshold will be assessed and the results will be recorded. Data will be analyzed statistically and the results will be reported.

Recruitment & Eligibility

Inclusion Criteria

Chronic knee osteoarthritis (more than 3 months) 2.
Conservatively managed or pre-operative knee osteoarthritis cases 3.
Pain severity of more than 3 out of 10 on the Numeric Pain Rating Scale (NPRS) 4.
Radiologically (Kellgren Lawrence grade of more than 0) or clinically (ACR criteria) diagnosed knee osteoarthritis 5.
Can read and understand English and/or Kannada 6.
Cognitively sound.

Exclusion Criteria

Known case of neurological disorder (e.g., peripheral neuropathy, stroke, GBS, multiple sclerosis, spinal cord lesion, cognitive impairment) 2.
Known case of systemic disorder (e.g., rheumatoid arthritis, SLE, fibromyalgia) 3.
Skin lesion at assessment site 4.
Pain for more than 3 months in areas other than the knee (e.g., chronic low back pain).

Primary Outcome Measures

Name	Time	Method
3) Percentage change in pain severity in weight-bearing activities	One time assessment at the time of recruitment
4) Percentage change in pain severity in non-weight-bearing activities	One time assessment at the time of recruitment
1) Numeric Pain Rating Scale (NPRS) score in weight-bearing activities	One time assessment at the time of recruitment
2) Numeric Pain Rating Scale (NPRS) score in non-weight-bearing activities	One time assessment at the time of recruitment

Secondary Outcome Measures

Name	Time	Method
1. Wind-up ratio	2. Pain pressure threshold

Locations (1): Kasturba Hospital
🇮🇳
Udupi, KARNATAKA, India
Kasturba Hospital
🇮🇳Udupi, KARNATAKA, India
Isha Agrawal
Principal investigator
9113012403
agrawal.nitinkumar@learner.manipal.edu