evels of Biomarkers of Inflammation and Oxidative Stress in Serum and Aqueous of Patients with Polypoidal Choroidal Vasculopathy
- Conditions
- 8-isoprostaneMCPǃMitoSoxMitotrackerPolypoidal choroidal vasculopathyafilbercepyeyleabiomarker
- Registration Number
- TCTR20190506004
- Lead Sponsor
- Faculty of Medicine, Chiang Mai University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
PCV patient group
1.age greater than 18 years
2.Diagnosis of PCV in each or both eyes without previous treatment except pneumatic displacement
3.Diagnosis of PCV followed fundus photo, polyp lesion from ICGA, and the diagnostic criteria of the EVEREST study
4.No other retinal diseases
5.Visit Maharaj Nakorn Chiang Mai hospital between 1st February 2017-31st January 2019
6.No arthlerosclerotic diseases or uncontrolled metabolic diseases
control group
1.Diagnosis of Senile cataract in each or both eyes without previous treatment and need to go on cataract surgery in Maharaj Nakorn Chiang Mai hospita
2.No other eye diseases
3.Demographic data is correlated with PCV patient group
4.Consent was approved from patient
1.Have condition that obscure the fundus photo picture
2.Have systemic inflammatory condition or Using drug that interfere the process of inflammatory reaction
3.Have previous intraocular surgery or intravitreal injection
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method biomarker between PCV patients and control group baseline (day 0) Serum and aqueous analysis
- Secondary Outcome Measures
Name Time Method biomarker between respone and non-response PCV patients baseline (day 0), 8 weeks, 24 weeks, 48 weeks serum and aqueous analysis,biomarker in non-response PCV patients after treatment with N-acetyl cysteine 48 weeks serum and aqueous analysis