A DOUBLE-BLIND RANDOMISED CONTROLLED TRIAL ON THE EFFECT OF DEXMEDETOMIDINE ON TRACHEAL RESPONSE WHEN ADMINISTERED BY INTRANASAL DROP VERSUS NEBULISATION DURING EXTUBATION.

Not yet recruiting

Conditions: Medical and Surgical,

Registration Number: CTRI/2022/11/047245

Lead Sponsor: Self

Brief Summary: Dexmedetomidine is a highly selective alpha 2 adrenergic receptor agonist that acts on the locus ceruleus to produce dose dependent sedation with no respiratory depression and only modest hemodynamic effects. The aim is to compare the efficacy of two methods of administering intranasal Dexmedetomidine on the quality of extubation, hemodynamic responses and post operative sedation .

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 90

Inclusion Criteria

1.Patients posted for elective surgeries under general anesthesia 2.American Society of Anesthesiologists (ASA) physical status I and II 3.Age: 20 â€“ 60 Years 4.Surgeries with a duration of 60-120 minutes.

Exclusion Criteria

1.Patients with any nasal pathologies like nasal polyp 2.Patients undergoing upper thoracic and cardiovascular surgeries.
3.History of allergy to the drugs, which will be used in the study.
4.Patients with psychiatric disorders.
5.Patients on anti-hypertensive medications 6.Pregnant women 7.Surgeries with a duration of less than 60 minutes or beyond 150 minutes.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the quality of extubation and stress response during extubation.	1 minute post extubation \| 3 minutes post extubation \| 5 minutes post extubation \| 10 minutes post extubation \| 15 minutes post extubation

Secondary Outcome Measures

Name	Time	Method
To assess the post-operative sedation score with Ramsay Sedation Score	1. At the time of arrival in post-operative room

Trial Locations

Locations (1): Kalinga Institute of Medical Sciences
🇮🇳
Khordha, ORISSA, India
Kalinga Institute of Medical Sciences
🇮🇳Khordha, ORISSA, India
Dr Supriya Jena
Principal investigator
8895607770
drsupriyajena@gmail.com