Periodontitis and type 2 diabetes mellitus

Phase 3

Completed

• Conditions: Topic: Diabetes Research Network, Oral and Gastrointestinal; Subtopic: Type 2, Oral and Gastrointestinal (all Subtopics); Disease: Cardiovascular disease, Diabetic Control, Other, Oral & Dental; Nutritional, Metabolic, Endocrine; Diabetes mellitus

• Registration Number: ISRCTN83229304
• Lead Sponsor: CL Eastman Dental Institute and Hospital, University College London (UK)

Brief Summary

2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30472992

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-06-18
• Study Completion: 2015-01-01
• Last Update Posted: 18 March 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 280

Inclusion Criteria

1. Subject aged over 18 years, either sex
2. Subject diagnosed with type 2 diabetes mellitus
3. Subject consenting to the study
4. Subject with signs of active moderate to severe periodontitis (at least 20 periodontal pockets, probing pocket depth [PPD] greater than 4 mm and bleeding on probing)
5. Minimum of 15 teeth present

Exclusion Criteria

1. Pregnancy/lactation
2. Subjects on chronic treatment with phenytoin or cyclosporin
3. Subjects with known human immunodeficiency virus (HIV) or hepatitis (B, C) or uncontrolled systemic diseases (cardiovascular diseases including hypertension, liver, pulmonary diseases, end stage renal failure) and/or neoplasm
4. Subjects who require antibiotic coverage for periodontal procedures

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in HbA1c between test and control group after 12 months of completion of therapy