Effect of Dexmedetomidine Versus Ketamine on Patients of Laryngeal Microsurgery: a Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 168
- 试验地点
- 1
- 主要终点
- incidence of postoperative sore throat
研究概览
简要总结
compare effect of IV dexmedetomidine and ketamine on pain score, perioperative hemodynamics and detect side effects of dexmedetomidine and ketamine.
详细描述
Microlaryngeal surgery is a common surgical procedure now a days which is associated with many complications such as postoperative pain, airway edema and persistent cough
. the study is to compare the effect of IV dexmedetomidine and ketamine on pain score, perioperative hemodynamics and to detect side effects of dexmedetomidine and ketamine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 18-70 years ASA I,II
排除标准
- •CVdiseases as IHD and severe valvular disease.
- •allergy to ketamine or dexmedetomidine.
- •Patients refusal
- •Suspected difficult intubation more than 2 trials
研究组 & 干预措施
Control
saline before induction infusion till end of surgery
干预措施: Saline (control group) (Drug)
Dexmedetomidine
1.0mcg/kg of dexmedetomidineloading dose before induction then 0.5 mcg/kg/hr of infused till end of surgery
干预措施: Dexmedetomidine (Drug)
Ketamine
0.25 mg/kg/hr ketamine infused till end of surgery
干预措施: Ketamine (Drug)
结局指标
主要结局
incidence of postoperative sore throat
时间窗: 30 minutes postoperative
incidence of postoperative sore throat
次要结局
- Heart Rate(1hour postoperative)
- oxygen saturation(1hour postoperative)
- incidence of complications(1hour postoperative)
- Ramsey sedation score(1hour postoperative)
- postoperative cough incidence(1hour postoperative)
- Mean Arterial Pressure(1hour postoperative)
研究者
Dalia Ismail
Associate Professor of Anesthesia, Surgical ICU and pain management at Faculty of medicine Cairo University
Cairo University