Acute effects of different nicotine applications on small airway stiffness, maximal exercise capacity, and arterial vessel stiffness during and after exercise situations on a bicycle
- Conditions
- inhalative and non-inhalative nicotine consumption
- Registration Number
- DRKS00030564
- Lead Sponsor
- KSH Lübeck
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 20
Age of at least 18 years
-BMI 20-27,5kg/m²
-no previous medical conditions
-occasional but not daily nicotine consumption - e.g. via filter cigarette
-consent to the study protocol with written informed consent
-pregnancy excluded or safe continued hormonal contraception
-strict non-smokers
-People who have consumed nicotine within 48h before the measurement
-Disorders of the musculoskeletal system that do not allow spiroergometry to be performed
-acute viral or bacterial infections
-serious illnesses which, in the opinion of the study directors, endanger the safety of the participant during the study, especially during exercise
-serious arrhythmias, heart defects
-pregnancy or lactation
-drug abuse other than nicotine
-Participation in another drug or medical device study
-lack of compliance
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Maximum oxygen uptake after consumption of various nicotine applications compared to a control group.
- Secondary Outcome Measures
Name Time Method -Comparison of the four experimental arms before performing spiroergometry regarding peripheral and central hemodynamics as well as arterial vascular stiffness and small airways.<br>-Variation of the mentioned parameters after the exercise situation over 30 minutes with set measurement time points (Mobil-O-Graph every 5 minutes, Small Airways after 5, 10, 15 and 30 minutes). <br>-Comparison of parameters of physical performance, heart rate and airway reserve of the four experimental arms.