Influences of different nicotine applications on peripheral and central hemodynamic as well as on arterial stiffness and endothelial dysfunctio

Not Applicable

• Conditions: Generalized and unspecified atherosclerosis; Smokerhealthy volunteers; I70.9

• Registration Number: DRKS00012919
• Lead Sponsor: niversitätsklinikum Schleswig-Holstein Campus Lübeck

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-08-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

age over 18 years
- active smoking
- written consent to the study protocol
- female smokers under oral contraceptives (to avoid hormonal/cyclic dependencies)

Exclusion Criteria

- non smoking
- pregnancy or lactation
- drug or alcohol abuse
- participation in other clinical trials
- lack of compliance

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome is the measurement of the nicotine concentration in the blood ten minutes after the nicotine application and during follow-up after one and two hours as well as the changes in blood pressure.

Secondary Outcome Measures

Name	Time	Method
Secondary outcomes include changes in peripheral and central hemodynamics, arterial stiffness, endothelias dysfunction and inflammatory markers depending on the various nicotine applications for two hours after vaping e.g. smoking.