actobacillus supplement intake test

Not Applicable

• Conditions: healthy volunteer

• Registration Number: JPRN-UMIN000025888
• Lead Sponsor: Beauty & Health Research_Inc

Brief Summary

This study was to investigate the effects of the intake of Lactobacillus rhamnosus GG (LGG) on the defecation and skin condition of healthy adults by a randomized, double-blind, placebo-controlled study. Total 96 healthy adult volunteers with a tendency of constipation and dry skin were given lyophilized cells of LGG (1.4x10^10cfu/g) or placebo for 4 weeks. The defecation frequency at week 4 significantly increased after intake in both LGG group and placebo group (p<0.01). Fecal quantity at week 4 tended to increase after intake in the LGG group (p<0.1). The stratum corneum hydration of the inner forearm was higher in the LGG group than in the placebo group (p<0.01). After week 4 in the LGG group, the transepidermal water loss from the cheek was lower than before intake. A questionnaire on the skin state indicated that skin condition of the LGG group became better than that of placebo group. These results indicate that oral administration of LGG could positively influence the moisture content of skin by increasing the stratum corneum hydration and by inhibiting transepidermal water loss.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-01-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

Not provided

Exclusion Criteria

1)Severe hay fever 2)Those who have allergic diseases such as atopic dermatitis and who are receiving medication under the supervision of a doctor 3)Currently, those who have some type of chronic illness and are undergoing drug treatment 4)Person who changes skin condition before and after menstruation 5)Persons who are allergic to dairy products 6)Those who participated in other clinical or monitoring studies within one month prior to the start of testing, those who wish to participate in other clinical trials during this study 7) Those who routinely use medicines and quasi drugs (constipation medicines, intestinal preparations, rough skin remedies, etc.) that may affect the results of this test within one month from the start of the test 8)Persons who are taking health foods, foods for specified health use, which are likely to affect the results of this test within the first month of the test, and those who intend to intake during the test 9)Those who are pregnant, planning to become pregnant during the examination, those who have hope, those who are breastfeeding 10)Those planned to go abroad or domestic travel during the examination period 11)Those who are scheduled to undergo major changes in the living environment such as relocation and relocation during the examination period 12)In addition, those who judged that the examination responsible doctor is inappropriate as a subject including health and living aspects

Study & Design

• Study Type: Interventional
• Study Design: Not specified