NCT04253470CompletedNot Applicable
The Neverending Debate on Progesterone Elevation: Possible Solutions
Istituto Clinico Humanitas1 site in 1 country8,000 target enrollmentStarted: January 1, 2012Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 8,000
- Locations
- 1
- Primary Endpoint
- Impact of PE on CPR and LBR
Study Overview
Brief Summary
The association between serum progesterone (P) levels, measured on the day of ovulation trigger, and the outcome of in vitro fertilization cycles, has been one of the major controversies in the field of ovarian stimulation endocrinology.
This is a single-center retrospective cohort study. Study duration period is from January 2012 to December 2016.
All fresh embryo transfer (ET) both at cleavage stage and blastocyst stage, performed in Humanitas Fertility Center during the study period, were included.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •All fresh embryo transfers both at cleavage stage (Day 2 and Day3) and blastocyst stage (Day 5)
- •Thawed embryo transfer deriving from supernumerary embryos cycles, by P increase, by OHSS, by other reasons (i.e inadequate endometrium, medical complications, etc)
Exclusion Criteria
- •thawed embryo transfers deriving from PGTA.
Outcomes
Primary Outcomes
Impact of PE on CPR and LBR
Time Frame: January 2012-December 2016
To evaluate the impact of premature high serum P levels on the outcome of fresh embryo transfer cycles in terms of Clinical Pregnancy Rates (CPR) and Live Birth Rates (LBR).
Secondary Outcomes
- Blastocyst embryo transfers' outcomes in PE(January 2012-December 2016)
Investigators
Study Sites (1)
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