Double Trigger in Patients With Low Proportion of Mature Oocytes

Phase 2

• Conditions: Infertility, Female
• Interventions: Drug: Double trigger; Drug: HCG trigger

• Registration Number: NCT04407052
• Lead Sponsor: Riyadh Fertility and Reproductive Health center

Brief Summary

The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the number of mature oocytes in patients with history of low proportion of mature oocytes in previous IVF cycle triggered by HCG.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-05
• Study First Submitted: 2020-05-25
• Study First Submitted QC: 2020-05-28
• Last Update Submitted: 2020-05-28
• Study First Posted: 2020-05-29
• Last Update Posted: 2020-05-29
• Study Start: 2020-05-30
• Primary Completion: 2020-12-31
• Study Completion: 2021-02-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 66

Inclusion Criteria

• Patients with history of low proportion of mature oocytes in previous IVF attempt (triggered by HCG).
• Patients with 6 to 15 mature follicles on the day oocyte trigger in the current IVF-ET attempt

Exclusion Criteria

• Endometriosis
• PCOS

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Double trigger	Double trigger	GnRH-agonist and HCG are used to trigger ovulation
HCG	HCG trigger	HCG is used to trigger ovulation

Primary Outcome Measures

Name	Time	Method
Number of oocytes retrieved	First day after oocyte retrieval

Secondary Outcome Measures

Name	Time	Method
Clinical pregnancy rate	First 5 weeks after oocyte retrieval	The presence of gestational sac detected by ultrasound examination

Trial Locations

Locations (1)

Riyadh Fertility and Reproductive Health center; 🇪🇬 Giza, Egypt