Effects of Pazopanib on Hereditary Hemorrhagic Telangiectasia Related Epistaxis and Anemia (Paz)
- Conditions
- Hereditary Hemorrhagic TelangiectasiaNosebleedHHTEpistaxisAnemia
- Interventions
- Drug: Placebo oral capsule
- Registration Number
- NCT03850964
- Lead Sponsor
- Cure HHT
- Brief Summary
During the Efficacy Study (Part B), the investigators will study whether Pazopanib, taken daily for 24 weeks, will reduce the severity of nose bleeds in patients with hereditary hemorrhagic telangiectasia (HHT). Patients will either be provided active drug or a placebo \[sugar - inactive pill\], and be tested for nose bleed severity throughout the trial, including particularly nose bleed duration. Investigators will also test for blood loss, as well as for safety. This study is funded by the US Department of Defense USAMRAA and FDA/OOPD.
- Detailed Description
Now that a single dose pharmacokinetics (PK) study (Part A) has been completed to properly establish similar exposure with the prior pilot 50mg tablet, a double blind, placebo controlled study will follow (Part B), which proposes to define primarily the value of low dose (150 mg) Pazopanib on nose bleed duration, in the context of assessing perceived nose bleed severity.
After a patient completes Part B of the study, the patient will be invited to take part in an Extension Study (Part C) in which the patient will be provided with active drug equal to the dose they were assigned in Part B. All patients in Part C will receive active drug for 24 weeks. Part C will further assess the effects of Pazopanib on the severity of nose bleeds in patients with HHT and also support safety and efficacy elements.
After the patient completes their treatment period (either Part B or Parts B and C), a 12 week follow-up period will follow to support safety and efficacy elements. Secondary endpoints will be assessed, including ongoing blood loss, use of iron and blood products, quality of life, and drug safety.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 70
Not provided
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Participant has known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to pazopanib that in the opinion of the investigator contradicts their participation.
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Currently has incompletely treated cerebral arterio-venous malformations (AVMs) or cerebral arteriovenous fistulas (AVFs) that are symptomatic or have high-risk features detected on either MRI/MRA or digital subtraction angiography. High-risk features include: microhemorrhage seen on MRI; feeding artery aneurysm, nidus aneurysm or venous outflow stenosis seen on MRA, CTA, or catheter angiography. Non-shunting vascular brain lesions such as capillary vascular malformations, telangiectasias, and cavernous malformations are not an exclusion criterion. (Note: MRI scan does not need to be repeated at screening if AVMs and AVFs were absent on a scan at age ≥18 years).
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Currently has perfused pulmonary AVMs with feeding artery diameter ≥ 3mm.
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Known significant bleeding sources other than nasal or gastrointestinal.
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Systemic use of a potent VEGF inhibitor (e.g., direct inhibitors of VEGF-receptor signaling such as sunitinib) in the 4 weeks prior to enrollment. Systemic use of bevacizumab in the 6 weeks prior to enrollment due to its longer half-life.
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Active and recent onset of clinically significant diarrhea.
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Current or recent (in the last 5 years) malignancies (except non-melanoma skin cancers)
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Participant has had major surgery (e.g. surgical ligation of an AVM) or trauma within 28 days or had minor surgical procedures (e.g. central venous access line removal) within 7 days prior to dosing, the latter representing a recent wound, fracture or ulcer
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Participant has a planned surgery during periods of active treatment and 6 weeks of follow up; case by case evaluation if PI desires inclusion with medical monitor agreement.
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Participant has clinically significant gastrointestinal abnormalities (other than hereditary hemorrhagic telangiectasia related vascular lesions).
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Participant during the 6 months prior to first dose of study drug has a history of cerebrovascular accident (including transient ischemic attacks), pulmonary embolism, untreated deep vein thrombosis (DVT), myocardial infarction, or any other thrombotic event.
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Presence of intrinsic heart disease as evidenced by any of the following: Echo derived left ventricular ejection fraction < 45%; Unstable obstructive CAD; history of MI, CABG, or PCI in the last 6 months; Infiltrative and/or restrictive cardiomyopathies; Significant pericardial disease; or clinical heart failure with more than moderate mitral valve or aortic valve disease. In the absence of clinical heart failure, EKG abnormalities, or known cardiac functional disease (e.g., MI or cardiomyopathy), a previous echo during adulthood is adequate. If there is history for coronary disease or cardiomyopathy, an echo in the past 5 years will be adequate for screening. If the patient has current clinical heart failure, a recent cardiac event in last 5 yrs, or a cardiac event since the most recent echo, an echo in the past 6 months will be necessary for screening. Clinical heart failure due to liver AVM or anemia, and not associated with the above findings (with an EF >=45%) will be eligible for enrollment.
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Unable or unwilling to discontinue use of prohibited medications list in Section 6.5.2 for at least 14 days or 5 half-lives of a drug (whichever is longer) prior to the randomization and for the duration of the study.
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The participant has participated in a clinical trial and has received an investigational product within the following time period prior to the start of randomization: 4 weeks, 4 half-lives or the duration of the biological effect of the investigational product (whichever is longer).
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QT corrected interval >450 msec for men or >460 msec for women, based on averaged QT corrected interval values of triplicate ECGs obtained over a brief recording period.
- History of familial prolonged QT.
- Any concomitant medication which is known to prolong QT.
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Average baseline hemoglobin <6 g/dL.
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Platelets < 75x10^9 /L.
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International normalized ratio (INR) > 1.5x ULN or activated partial thromboplastin time (aPTT) > 1.5x ULN (unless due to known concurrent medications, e.g. warfarin).
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Alanine Transaminase (ALT) >2 x upper limit of normal.
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Bilirubin >1.5x upper limit of normal (isolated bilirubin >1.5x upper limit of normal is acceptable if bilirubin is fractionated and direct bilirubin < 35%).
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Participant has poorly controlled hypertension [defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg]. If BP is poorly controlled at screen visit, initiation or adjustment of antihypertensive medication(s) is permitted during the run-in period prior to randomization. Prior to randomization, blood pressure must be assessed three times and the mean SBP/DBP must be < 140/90 mmHg in order for a patient to be randomized.
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Substantive renal disease (eGFR <30 mL/min/1.73m2calculated using the Cockcroft-Gault formula)
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Echo derived left ventricular ejection fraction < 45%.
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Thyroid stimulating hormone (TSH) > 1.5 x upper limit of normal.
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Urine protein to creatinine ratio > 0.4.
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Neutrophil count <1000 /mm^3.
Part C Eligibility
All patients who completed Part B will be eligible for Part C unless significant safety concerns have been raised.
Participants must be able and willing to sign the Extension ICF.
Neither the Study Doctor or the participant will be informed of which drug (active or placebo) received during Part B.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Part B (Severe Anemia) Pazopanib - 150 mg Pazopanib 150 mg pazopanib oral capsules (six 25 mg placebo capsules daily). Part B (Severe Anemia) Placebo Placebo oral capsule Placebo oral capsules (six 25 mg placebo capsules daily). Part B (Severe Epistaxis) Pazopanib - 150 mg Pazopanib Pazopanib 150 mg oral daily dosing (six 25 mg Pazopanib capsules). Part B (Severe Epistaxis) Placebo Placebo oral capsule Placebo oral capsules (six 25 mg placebo capsules daily). Part C Pazopanib - 150 mg Pazopanib Pazopanib 150 mg oral daily dosing (six 25 mg Pazopanib capsules).
- Primary Outcome Measures
Name Time Method Hemoglobin Response rate increase in hemoglobin Average duration in weeks 19-24 (last 6 weeks of blinded phase) versus baseline. Increase in hemoglobin by ≥ 2 g/dl in the 150 mg pazopanib arm versus the placebo arm (moderate and severe cohorts combined)
Change in epistaxis duration in minutes Average duration in weeks 19-24 (last 6 weeks of blinded phase) versus baseline. \>=50% decrease in the duration of epistaxis in the 150 mg pazopanib arm versus the placebo arm (moderate and severe cohorts combined)
- Secondary Outcome Measures
Name Time Method Achievement of meaningful improvement in epistaxis for HHT patients Baseline [screening, run-in and 0 time points] and week 24. Compare patients reported being bothered by epistaxis at baseline and report not bothered at week 24
Assess pharmacokinetics and pharmacodynamics (PK/PD) of treatment Weeks 12, 24, 36 and 48 * Cτ, data permitting
* Graphical exploration of PK/PD relationships between pazopanib and selected PD endpointsPercent change in blood transfusion rate in the Severe Cohort Baseline, and weeks 13-24 Reduction in RBC transfusion rate by at least one unit
Assess the safety of up to 24 and 48 weeks of treatment of pazopanib 1st dose of intervention until Weeks 24 and 48 * AEs; absolute values and changes over time of hematology, clinical chemistry, urinalysis, blood pressure, and heart rate.
* Physical exam, leg and abdominal evaluations, and CNS symptoms.
* ECG parameters (PR, QRS, QT, QTc intervals) in addition to cardiac echocardiogram to evaluate LV function from pre-dose values in at-risk patients (baseline EF \<50)Establish comparability of endpoint outcomes for each hemoglobin stratification Baseline, Weeks 19-24, Week 48 Trends for primary endpoint in severe (hemoglobin (\<9.5 g/dl) and moderate (9.5-10.9 g/dl) groups.
Trial Locations
- Locations (11)
University of California - Los Angeles
🇺🇸Los Angeles, California, United States
University of Colorado
🇺🇸Denver, Colorado, United States
Augusta University
🇺🇸Augusta, Georgia, United States
John Hopkins University
🇺🇸Baltimore, Maryland, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Washington University
🇺🇸St Louis, Missouri, United States
University of North Carolina
🇺🇸Chapel Hill, North Carolina, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
University of Texas - Southwestern
🇺🇸Dallas, Texas, United States
University of Utah Medical Center
🇺🇸Salt Lake City, Utah, United States