Comparison between the fluids Normal saline and Ringers Lactate in neurosurgery patients
Not Applicable
- Conditions
- Health Condition 1: C719- Malignant neoplasm of brain, unspecified
- Registration Number
- CTRI/2023/06/053974
- Lead Sponsor
- PGIMER CHANDIGARH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1) Adult patients scheduled for elective craniotomy for supratentorial tumors under
general anaesthesia with tumor volume <200ml, where mannitol is being used
routinely.
2) Patients above the age of 18 years and below 65 years.
3) ASA I to ASA III patients.
Exclusion Criteria
1) Patients with deep seated and skull base tumors.
2) Patients with tumor volume >200ml.
3) Patients with CKD or those undergoing renal replacement therapy.
4) Patients with Chronic liver disease.
5) Patients receiving diuretic therapy preoperatively.
6) Pre-existing dyselectrolytemia.
7) Massive intraoperative blood loss.
8) If the patient requires hyperventilation to paCO2 <30 mm Hg.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare measured values of serum osmolality in neurosurgical patients receiving <br/ ><br>Normal Saline vs Ringers Lactate during elective craniotomy for Supratentorial tumors <br/ ><br>at the end of the surgery.Timepoint: After Induction <br/ ><br>And At the end of surgery
- Secondary Outcome Measures
Name Time Method Brain Relaxation ScoreTimepoint: at dura opening and at closure;Changes in hemodynamic parametersTimepoint: every 15 min from induction.;Comparison of the following parameters from baseline amongst the groups <br/ ><br>â?¢ Rise in osmolality from baseline in each group <br/ ><br>â?¢ Serum electrolytes <br/ ><br>â?¢ pH <br/ ><br>â?¢ LactateTimepoint: After Induction <br/ ><br>And At the end of surgery;MRS at dischargeTimepoint: at discharge;Total Blood loss, Blood and blood products infusion.Timepoint: At the end of Surgery;Total urine outputTimepoint: At the end of Surgery;Total volume of fluid (crystalloids and colloids) used.Timepoint: At the end of Surgery