Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Inhibition score measured by the Think / No-Think Test
研究概览
简要总结
In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested.
This little-known pathology and notable psychiatric co-morbidities (depression, anxiety) can take in elderly subjects different masks that interfere with diagnosis and treatment.
The data in the literature suggest that this Post-Traumatic Stress Disorder with Delayed Expression (TSPT-R) may be related to a deficiency of the executive functions of inhibition, and more particularly a deficit of mental memory inhibition and therefore the removal of unwanted memories.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 85 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Regarding the constitution of the group patient (TSPT-R):
- •Subjects 65 years of age or older
- •Clinical diagnosis of delayed-onset PTSD according to DSM-5 criteria after 65 years
- •The traumatic event must have taken place at the latest before 65 years
- •Affiliated person or beneficiary of a social security scheme.
- •Written consent before any examination required by research)
- •Regarding the constitution of the control group:
- •Subjects 65 years of age or older
- •No diagnosis of PTSD (delayed or not) or history of PTSD (delayed or not)
- •Affiliated person or beneficiary of a social security scheme.
- •Written consent before any examination required by the research).
排除标准
- •For both groups:
- •Acute or chronic cognitive impairment known
- •GRECO MMSE pathological score less than or equal to the pathological threshold weighted according to level of education and age, namely:
- •22 if no diploma
- •23 if certificate of study
- •25 if patent
- •26 if bin or more
- •Remove one point at each threshold if age> 80 years
- •Sensory or motor disorder preventing the passing of different tests
- •Psychotic disorder
- •Mood disorder in decompensation (for depression, HAD-D score equal to or greater than 11)
- •Disorder of the use of a moderate or severe substance (except tobacco).
- •Patients under guardianship or curatorship.
研究组 & 干预措施
Patient (TSPT-R)
Post Traumatic Stress Disorder
干预措施: Post Traumatic Stress Disorder (Other)
control
No Post Traumatic Stress Disorder
干预措施: Post Traumatic Stress Disorder (Other)
结局指标
主要结局
Inhibition score measured by the Think / No-Think Test
时间窗: 1 month
the average of the inhibition score measured by the "Think / No-Think" test as defined by Anderson and Green (2001) and then reviewed by Anderson et al. in 2011
次要结局
未报告次要终点