Clinical Trials/EUCTR2006-002333-21-AT

EUCTR2006-002333-21-AT

Active, not recruiting

Not Applicable

Intraoperative Goal-Directed Fluid Therapyin Lean and Obese Patients - n.A

Allgemeines Krankenhaus Wien, Medizinische Un iversität Wien0 sites40 target enrollmentJune 23, 2006

ConditionsHemodynamics in obese patients differ from lean patients: Obese patients have a higher cardiac output, the absolute amount of their intravascular volume is increased, as is the intracellular volume. The impact of these pathophysiological changes on perioperative fluid therapy is not known. Fluid optimisation has been considered as major contributor to improved oxygen delivery in patients. Hypovolemia has been associated with significant increases in morbidity and mortality.

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Hemodynamics in obese patients differ from lean patients: Obese patients have a higher cardiac output, the absolute amount of their intravascular volume is increased, as is the intracellular volume. The impact of these pathophysiological changes on perioperative fluid therapy is not known. Fluid optimisation has been considered as major contributor to improved oxygen delivery in patients. Hypovolemia has been associated with significant increases in morbidity and mortality.
Sponsor: Allgemeines Krankenhaus Wien, Medizinische Un iversität Wien
Enrollment: 40
Status: Active, not recruiting
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

No summary available.

Registry

who.int

Start Date

June 23, 2006

End Date

TBD

Last Updated

12 years ago

Study Type

Interventional clinical trial of medicinal product

Sex

Female

Investigators

Sponsor

Allgemeines Krankenhaus Wien, Medizinische Un iversität Wien

Eligibility Criteria

Inclusion Criteria

•After IRB approval and written informed consent patients, aged 18\-80, and scheduled consecutively for elective abdominal hysterectomy or myomectomy will be included in the study. Patients will be assigned to four groups.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1\.2 Adults (18\-64 years) yes
•F.1\.2\.1 Number of subjects for this age range
•F.1\.3 Elderly (\>\=65 years) yes
•F.1\.3\.1 Number of subjects for this age range

Exclusion Criteria

•We will exclude patients having cardiac (ejection fraction\<35%) or renal insufficiency (creatinine clearance \< 30ml/min, or on renal replacement therapy), coronary (NYHA IV) or peripheral artery disease, insulin dependent diabetes mellitus, coagulopathies, symptoms of infection or sepsis, or a history of susceptibility to malignant hyperthermia or porphyria. Participants in other studies will be excluded, when an interference of the studies cannot be ruled out.

Outcomes

Primary Outcomes

Not specified

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