Does intra-operative goal directed fluid therapy (GDT) alter microvascular circulation and reduce clinically important post-operative complications in patients undergoing elective major abdominal surgery?

Plymouth Hospitals NHS Trust (UK)0 个研究点目标入组 220 人开始时间: 2012年7月26日最近更新: 2016年10月17日

适应症

试验速览

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•Absolute: Unwillingness to participate Inability to perform the tests and consent within the timetable for elective surgery Withdrawn by anaesthetist or surgeon Requirement by the attending anaesthetist to use cardiac output monitoring based on clinical need Acute myocardial infarction (3-5 days) Unstable angina Uncontrolled arrhythmias causing symptoms or haemodynamic compromise Syncope Active endocarditis Acute myocarditis or pericarditis Symptomatic severe aortic stenosis Uncontrolled heart failure Acute pulmonary embolus or pulmonary infarction Thrombosis of lower extremities Suspected dissecting aneurysm Uncontrolled asthma Pulmonary edema Room air desaturation at rest < 85%* Respiratory failure Acute noncardiopulmonary disorder that may affect exercise performance or be aggravated by exercise (i.e. infection, renal failure, thyrotoxicosis)
•Relative: Left main coronary stenosis or its equivalent Moderate stenotic valvular heart disease Severe untreated arterial hypertension at rest (200 mm Hg systolic, 120 mm Hg diastolic) Tachyarrhythmias or bradyarrhythmias Highdegree atrioventricular block Hypertrophic cardiomyopathy Significant pulmonary hypertension Advanced or complicated pregnancy Electrolyte abnormalities Orthopaedic impairment that compromises exercise performance

发起方

Plymouth Hospitals NHS Trust (UK)