To study whether three concentrations of oxygen used during operation Will affect the ability to fight infections undergoing in patients under going surgery for cancer of large intestine – An experimental study
Not Applicable
- Conditions
- Health Condition 1: C18- Malignant neoplasm of colon
- Registration Number
- CTRI/2022/07/043768
- Lead Sponsor
- Department of Health Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA I, II patients of either sex between the ages of 18-70 years, having a body mass index between 18-30 kg/m2 and posted for surgery for colonic malignancies will be included in this study.
Exclusion Criteria
Patients receiving preoperative chemotherapy, refusal to participate in the study, perioperative blood transfusions, chronic opioid use, renal failure, liver failure, congestive heart failure and co-morbid hematological diseases will be excluded from the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary end point of the study will be effect of different FiO2 on NK cell count (CD56, CD6)Timepoint: Perioperative period
- Secondary Outcome Measures
Name Time Method The secondary end points will be effect of different FiO2 on <br/ ><br>a.The total T lymphocyte count and counts for the T lymphocyte subpopulations, CD3, CD4, CD8, Th1 and Th2cells. <br/ ><br>b.Postoperative complications in patients undergoing surgery for colonic malignancies. <br/ ><br>Timepoint: Perioperative period