The Effects of Passive Heat Therapy in Patients With Chronic Kidney Disease

Not Applicable

Completed

• Conditions: Renal Insufficiency, Chronic
• Interventions: Procedure: Whole-body Passive Heat Therapy (HT); Procedure: Thermoneutral Control (CON)

• Registration Number: NCT05924919
• Lead Sponsor: Virginia Commonwealth University

Brief Summary

The objective of this proposal is to investigate the acute effects of whole-body passive heat therapy using far-infrared technology on vascular function, exercise capacity, and renal function in CKD patients. The central hypothesis is that an acute bout of whole-body passive heat therapy will be well-tolerated and lead to acute improvements in large blood vessel (macrovascular) function, small blood vessel (microvascular) function, and exercise capacity without significantly altering markers of acute kidney injury.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-05-25
• Study First Submitted QC: 2023-06-20
• Study First Posted: 2023-06-29
• Study Start: 2023-09-18
• Primary Completion: 2024-03-19
• Study Completion: 2024-03-19
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-07
• Last Update Posted: 2024-10-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Experimental Arm: Whole-body Passive Heat Therapy (HT)	Thermoneutral Control (CON)	Heat therapy will be administered using an infrared sauna. The intervention duration will last 25 minutes at a temperature of 60°C.
Experimental Arm: Whole-body Passive Heat Therapy (HT)	Whole-body Passive Heat Therapy (HT)	Heat therapy will be administered using an infrared sauna. The intervention duration will last 25 minutes at a temperature of 60°C.

Primary Outcome Measures

Name	Time	Method
Renal Safety of Heat Therapy	Change from baseline to 90 minutes after intervention	Change in urinary NGAL
Tolerability of Heat Therapy as Assessed using Validated Questionnaires of Thermal Perception	During 25 minute intervention	Self reported perception of heat using the the Thermal Sensation Scale.

Secondary Outcome Measures

Name	Time	Method
Conduit artery endothelial function	90 minutes after intervention	Brachial artery flow-mediated dilation assessed by high-resolution duplex ultrasound.
Lower Limb Microvascular Function	90 minutes after intervention	Lower limb microvascular function will be assessed with high-resolution duplex ultrasound during passive leg movement (PLM) technique.
Exercise Capacity	90 minutes after intervention	The 6-minute walk test distance.

Trial Locations

Locations (1)

Virginia Commonwealth University; 🇺🇸 Richmond, Virginia, United States