The impact of passive heat treatment on skeletal muscle perfusion capacity and post-prandial muscle protein synthesis rates in healthy older adults.

Recruiting

Conditions: anabole resistentie
muscle growth
muscle protein synthesis

Registration Number: NL-OMON50238

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 14

Inclusion Criteria

Healthy volunteers between the age 65 and 85 years

Exclusion Criteria

• Allergy for one of the food items used
• >5% weight change in the previous 6 months
• Participating in a structured (progressive) exercise program
• Frequent (more than once per week) user of infrared (or traditional) sauna in
the past 3 months
• Smoking
• Diagnosed cardiovasular disease
• Diagnosed musculoskeletal, GI tract, metabolic (e.g. diabetes) or pulmonary
(e.g. COPD) disorders
• Use of any medications known to affect protein metabolism (i.e.
corticosteroids, non-steroidal anti-inflammatories).
• Chronic use of gastric acid suppressing medication and/ or anti-coagulants
• Recent (<1 year) participation in amino acid tracer
(L-[ring-13C6]-phenylalanine and L-[3,5-2H2]-tyrosine) studies
• Blood donation in the past 2 months
• Strict vegetarian diet
• Known allergic reaction to ultrasound contrast agent

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Fractional synthetic rate (FSR) of muscle protein synthesis (MPS) over the 4<br /><br>hour period following meal ingestion</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoint is the skeletal muscle microvascular perfusion capacity in<br /><br>rest and 1h following meal ingestion assessed by contrast enhanced ultrasound.<br /><br>change in post-prandial plasma amino acid, glucose and insulin concentration.<br /><br>Changes in type I and type II muscle fiber capillarization assessed in the<br /><br>post-absorptive muscle biopsy samples by the use of immunohistochemistry</p><br>