Prospective evaluation of the comparability of different imaging methods for the detection and characterization of sentinel lymph nodes in cervical cancer and endometrial carcinoma
- Conditions
- C54.1C53EndometriumMalignant neoplasm of cervix uteri
- Registration Number
- DRKS00014346
- Lead Sponsor
- niversitätsklinikum Tübingen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 362
Inclusion Criteria
Patients with cervical cancer or endometrial cancer with a clinical indication for PET/MRT-examination for i) primary staging or re-staging in advanced disease, ii) unclear diagnosis based on conventional imaging procedures for op-planning, iii) pre-op exclusion of pelvine metastasis in case of pelvine relapse
- Age: =18 years
- Written informent consent
Exclusion Criteria
- Histologic type of carcinosarcoma or other rare entities
- Precnancy or breast feeding women
- No written informed consent
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation of different imaging methods for the detection of SLN (SPECT/CT, intra-op staining methods, PET/MRT) – among each other and in correlation to gold standard (immunohistological analysis) – for the pre-op localization of tumor-positive / tumor-negative S
- Secondary Outcome Measures
Name Time Method What is the predictive value of the combination of different imaging methods for tumor-positive SLN?<br>To do so: evaluation of sensitivity, specificity, accuracy as well as positive/negative predictive value of single imaging methods or combinations thereof for the detection of positive/negative SLN in patients with endometrial or cervical cancer – compared to gold standard (histopathological analyses of SLN).<br>