The Impact of Altered Arterioventricular Coupling on Central Cardiovascular Energy Delivery

Completed

• Conditions: Cardiovascular Diseases

• Registration Number: NCT03656757
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

This study will assess the amount of energy that the heart will deliver to the central circulation and the efficiency of that energy transfer, in patients undergoing a coronary artery bypass graft operation. Measurements will be taken just after induction of anaesthesia and repeated just after the end of the operation. The total energy delivered by the heart will be calculated by multiplying a pressure curve from the artery in the hand with the instantaneous ultrasound recorded cardiac output flow curve. The energy responsible for the acceleration of the blood volume, known as oscillatory power will also be calculated. The energy transfer will be calculated using a mathematical model based upon other ultrasound and blood pressure recorded variables. We would like to see if any alteration in energy delivered is in part due to impairment in energy transfer or alteration of fraction of oscillatory power rather than a change in total energy production. We would also like to study if there are changes in the oscillatory power after cardiac bypass surgery. The patients will be sampled sequentially into the study. We are not aware of any such studies undertaken in humans previously.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-08-31
• Study First Submitted QC: 2018-08-31
• Study First Posted: 2018-09-04
• Study Start: 2019-01-02
• Status Verified: 2019-03
• Primary Completion: 2019-03-13
• Study Completion: 2019-03-13
• Last Update Submitted: 2019-03-19
• Last Update Posted: 2019-03-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• Elective Coronary Artery Bypass Graft patients
• No contraindications to transoesophageal Echo
• Ejection fraction 40% or over

Exclusion Criteria

• Lack of consent
• Emergency operation
• Prosthetic aortic valve

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Arterioventricular coupling	1 day	The ratio between arterial elastance and ventricular elastance
Oscillatory Cardiac Power	1 day	The part of total cardiac power which is responsible for acceleration of the blood volume during systole.
Total Cardiac Power	1 day	The amount of energy per second delivered from the left ventricle to the arterial circulation

Secondary Outcome Measures

Name	Time	Method
Heart rate	1 day	The amount of heart beats per minute
Cardiac Output	1 day	The hearts delivery of volume per minute
Systemic vascular resistance	1 day	The resistance to flow of the arterial tree

Trial Locations

Locations (1)

St Olavs Hospital; 🇳🇴 Trondheim, Norway