Establishment of Ideal IV Sedative Regimen for Successful Fiberoptic Bronchoscopy in Assessing the Site, Severity of Sleep Apnea Syndrome
Overview
- Phase
- Not Applicable
- Intervention
- dexmedetomidine infusion rate, 0.5 mcg/kg/hr
- Conditions
- Sleep Apnea Syndrome
- Sponsor
- Yonsei University
- Enrollment
- 31
- Locations
- 1
- Primary Endpoint
- Desaturation rate
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Venous thromboembolism(VTE) is the third most common cardiovascular complication among hospitalized patients, and can even cause death. VTE often occurs in intensive care patients and there had been many efforts to prevent such complication. The American College of Chest Physicians (ACCP) had published evidence-based clinical practice guideline for VTE prophylaxis.
This study focuses on how VTE prophylaxis is being performed in both medical and surgical ICUs in a single University hospital, and sees the differences in such prophylactic patterns.
Investigators
Eligibility Criteria
Inclusion Criteria
- •20-60 years old patients with ASA class I-II
- •Scheduled for drug induced sleep endoscope after diagnosed with sleep apnea syndrome
Exclusion Criteria
- •Patients having hearing difficulties, taking any CNS related medication, history of any adverse drug reaction, Glasgow coma scale \< 15
- •Patients with severe cardiopulmonary dysfunction
- •Patients refusal
Arms & Interventions
dexmedetomidine 0.5 mcg/kg/hr
Intervention: dexmedetomidine infusion rate, 0.5 mcg/kg/hr
dexmedetomidine 1.0 mcg/kg/hr
Intervention: dexmedetomidine infusion rate, 1.0 mcg/kg/hr
Outcomes
Primary Outcomes
Desaturation rate
Time Frame: Baseline from 5 min after remifentanil TCI start, 10 min after dexmedetomidine loading start, every 5 min until surgeon can do endoscopy successfully, to immediately after endoscopy
SpO2 \< 90% (checked by pulse oximetry)