Prescribing Appropriateness of Thrombo-prophylaxis in Intensive Care Unit of Tertiary Hospital

Completed

• Conditions: DVT
• Interventions: Other: DVT prophyllaxis

• Registration Number: NCT06539156
• Lead Sponsor: Ain Shams University

Brief Summary

Hospitalized patients are at high risk of venous thromboembolism (VTE), and the appropriate use of thromboprophylaxis can significantly reduce the incidence of VTE in high-risk patients. We investigated the pattern of VTE prophylaxis administration among elderly medical patients and assessed its appropriateness based on the American College of Chest Physicians (ACCP) recommendations. Methods A cross-sectional single-center study will be conducted between July 2024 and December 2024, including hospitalized (\> 48 h), (≥ 60 years), medical and surgical patients, and excluding patients receiving anticoagulant for other reason, having contraindication to thromboprophylaxis, or had VTE diagnosed within 48 h. The Padua and caprine prediction scores will be used to determine the patients' risk for VTE, and thromboprophylaxis use will be assessed against the ACCP recommendations.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-07-29
• Study Start: 2024-08-01
• Study First Submitted QC: 2024-08-02
• Study First Posted: 2024-08-06
• Status Verified: 2024-12
• Primary Completion: 2024-12-01
• Study Completion: 2024-12-01
• Last Update Submitted: 2024-12-24
• Last Update Posted: 2024-12-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

Patient records

• admitted to the ICU with
• medical or surgical causes
• recieved anticoagulants for DVT prophylaxis

Exclusion Criteria

• Patients already on anticoagulant therapy,
• had history of previous DVT,
• had End-stage liver disease,
• admitted with hemorrhage/bleeding
• not prescribed DVT prophylaxis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Medical Patients	DVT prophyllaxis	-
Surgical Patients	DVT prophyllaxis	-

Primary Outcome Measures

Name	Time	Method
Padua score for medical patients	within 24 hours of ICU admission	Venous thromboembolism Risk assessment (Scores 0-3 are low risk and do not warrant prophylaxis. Scores ≥4 are high risk for VTE and subsequent complications; recommendation for thromboprophylaxis.)
Caprini score for surgical patients	within 24 hours of ICU admission	Venous thromboembolism Risk assessment (Total score of 0-1: Low risk of VTE Total score of ≥3: High/moderate risk of VTE )

Secondary Outcome Measures

Name	Time	Method
Adverse drug reaction cost	within 24 hours of ICU admission till ICU discharge (at least 48 hours)	sum of costs related to the Adverse drug reaction for DVT Prophylaxis
Bleeding risk assessment	within 24 hours of ICU admission
Direct Anticoagulant cost	within 24 hours of ICU admission till ICU discharge(at least 48 hours)	sum of costs related to the anticoagulant administration for DVT Prophylaxis

Trial Locations

Locations (1)

Teachers Hospital; 🇪🇬 Cairo, Egypt