Hyperalgesia After Deep Electrical Stimulation in Pain Free Subjects
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Rigshospitalet, Denmark
- Enrollment
- 21
- Locations
- 1
- Primary Endpoint
- Change in skin pain detection threshold before and during deep electrical pain stimulation.
Study Overview
Brief Summary
Sensory disturbances in persistent postherniotomy pain, include hyperalgesia from deeper structures as well as the skin. Whether this is one combined pain syndrome, where for instance deep pain leads to cutaneous hyperalgesia, or two isolated synchronous pain conditions, is unknown. By Giving pain free subjects an intense non-harmful electrical stimulation in deeper tissues in the groin and recording the skin sensory function, this hypothesis will be tested
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •male, age >18 yr, pain-free, caucasian
Exclusion Criteria
- •previous groin surgery, groin hernia, sensory disturbaces, use of painmedication, drug or alcohol abuse.
Outcomes
Primary Outcomes
Change in skin pain detection threshold before and during deep electrical pain stimulation.
Time Frame: 14 days
Heat pain detection threshold by use of a Thermotester (Somedic AS Sweden) is assessed before and during deep electrical pain stimulation (6 of 10 point on a NRS scale. Deep pain stimulation is performed by two needle electrodes, placed under ultrasound guidance, 5 mm apart in various tissue and locations in the groin: 1. Musculus rectus abdominis dxt. ( 10 cm craniel to the external inguinal ring) - Subcutaneous, and muscular stimulation. 2. Spina iliaca anterior superior dxt. ( 2 cm lateral to the ilica spine) - subcutaneous, m obliquus externus and nervns ilioinguinalis stimulation. 3. External inguinal ring - subcutaneous and funicle stimulation.
Secondary Outcomes
- Test-retest of primary outcome(14 days)
Investigators
Eske Kvanner Aasvang
M.D.
Rigshospitalet, Denmark