Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy
Withdrawn
- Conditions
- Septic ShockSevere Sepsis
- Interventions
- Procedure: continuous veno-venous hemodialysis
- Registration Number
- NCT01926301
- Lead Sponsor
- Johannes Gutenberg University Mainz
- Brief Summary
The cerebrovascular autoregulation is impaired in patients with severe sepsis and septic shock. A continuous veno-venous hemodialysis may improve impaired cerebrovascular autoregulation.
Hypothesis: continuous hemodialysis recovers impaired cerebrovascular autoregulation in patients with acute severe sepsis and septic shock.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- severe sepsis or septic shock
- adult patients
- possibility of transcranial Doppler ultrasound
Exclusion Criteria
- traumatic brain injury
- known cerebrovascular diseases
- Infection of the brain
- chronic renal failure
- pregnancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Hemodialysis continuous veno-venous hemodialysis Patients with severe sepsis or septic shock with acute renal failure and requirement of continuous veno-venous hemodialysis
- Primary Outcome Measures
Name Time Method Cerebrovascular autoregulation during the first 4 days Cerebrovascular autoregulation measured daily at the first 4 days of severe sepsis and septic shock
- Secondary Outcome Measures
Name Time Method Delirium at day 4 Incidence of Delirium at day 4 after severe sepsis or septic shock
Trial Locations
- Locations (1)
University Medical Center of the Johannes Gutenberg-Univerity
🇩🇪Mainz, Germany