Cerebrovascular Autoregulation During Sepsis

Completed

• Conditions: Sepsis; Delirium
• Interventions: Other: no interventions

• Registration Number: NCT01029080
• Lead Sponsor: Johannes Gutenberg University Mainz

Brief Summary

The aim of the study is to correlate the dynamic cerebrovascular autoregulation by patients with sepsis with a sepsis-associated delirium.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-12
• Study First Submitted: 2009-12-08
• Study First Submitted QC: 2009-12-08
• Study First Posted: 2009-12-09
• Primary Completion: 2010-12
• Study Completion: 2011-03
• Status Verified: 2013-04
• Last Update Submitted: 2013-04-12
• Last Update Posted: 2013-04-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• clinical symptoms of sepsis, severe sepsis and septic shock
• possibility for measurement of transcranial doppler ultrasound
• age over 18 years

Exclusion Criteria

• preexisting cerebrovascular disease
• preexisting immunological disease
• traumatic brain injury
• intracranial infectious disease
• pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Sepsis	no interventions	All patients with sepsis defined by actually sepsis guidelines

Primary Outcome Measures

Name	Time	Method
Disturbed cerebrovascular autoregulation correlates with sepsis associated delir	1 year	The Index of autoregulation (Mx) was measured and correlated with the clinical incidence of a sepsis associated delir

Secondary Outcome Measures

Name	Time	Method
Correlation between inflammatory parameters and disturbed cerebrovascular autoregulation	1 year
Correlation between inflammatory parameters and sepsis-associated delirium	1 year

Trial Locations

Locations (1)

University medical centre Mainz; 🇩🇪 Mainz, Germany