Cardiovascular and Cerebrovascular Control in Healthy Subjects

Recruiting

• Conditions: Autonomic Nervous System; Cerebral Autoregulation; Healthy
• Interventions: Diagnostic Test: active standing

• Registration Number: NCT05706532
• Lead Sponsor: IRCCS Policlinico S. Donato

Brief Summary

The aim of the study is to evaluate autonomic function and cerebrovascular control in 60 healthy subjects by means of noninvasive analysis of time series variability.

To this extent, heart period, systolic and mean arterial blood pressure, cerebral blood velocity, peripheral resistances, respiration will be recorded from subjects during an orthostatic challenge.

The interactions between autonomic cardiovascular function, cerebrovascular and peripheral control will be evaluated exploiting the most advanced signal processing techniques.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-01-23
• Study First Submitted QC: 2023-01-23
• Study First Posted: 2023-01-31
• Study Start: 2023-05-29
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-25
• Last Update Posted: 2025-03-28
• Primary Completion: 2027-10
• Study Completion: 2027-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• age >18
• sinus rhythm
• informed consent signed

Exclusion Criteria

• age <18
• presence of autonomic nervous system diseases or dysfunctions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy	active standing	30 healthy subjects; age \>18; sinus rhythm; absence of autonomic diseases or dysfunctions.

Primary Outcome Measures

Name	Time	Method
Evaluate the state and interactions of autonomic function and cerebrovascular control	12 months

Trial Locations

Locations (1)

IRCCS Policlinico San Donato; 🇮🇹 San Donato Milanese, Milan, Italy