Assessing cerebrovascular function using magnetic resonance imaging: A pilot study
- Conditions
- DementiaNeurological - Studies of the normal brain and nervous system
- Registration Number
- ACTRN12619001682134
- Lead Sponsor
- niversity of Auckland
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 10
•Healthy individuals
•Not taking any prescription or over-the-counter medications (other than oral contraceptive pill)
•Men and women
•Aged over 18 years
•Body mass index less than 30 kg/m2 (i.e. kilograms divided by height in metres squared)
•Body mass index less than 18 kg/m2 (i.e. kilograms divided by height in metres squared)
•Smokers
•Alcohol intake > 28 units/week
•Users of recreational drugs
•Cardiovascular disease (e.g., coronary heart disease, hypertension)
•Significant arrhythmias (e.g., atrial fibrillation, previous VT / significant ventricular ectopy)
•Severe respiratory disease (e.g., chronic obstructive pulmonary disease)
•Metabolic disease (e.g., type II diabetes)
•Cancer
•Connective tissue or inflammatory disease
•Neurological or cerebrovascular disease
•Infection or pyrexial illness
•Thyroid disorders
•Hepatic or renal impairment
•Outside the stated age range
•Current pregnancy
•Underlying medical conditions, which in the opinion of the Investigator place the participant at unacceptably high risk for participating in the study
•Inability to fully or appropriately provide consent (e.g., language issue, reading capability)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eurovascular coupling as assessed using a MRI scan.[Single timepoint of acquisition (i.e., at experimental session)]
- Secondary Outcome Measures
Name Time Method Cerebrovascular CO2 reactivity as assessed with a MRI scan.[Single timepoint of acquisition ]