Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke

Completed

• Conditions: Ischemic Stroke

• Registration Number: NCT02056821
• Lead Sponsor: Henry Ford Health System

Brief Summary

This study investigates if there are hemodynamic alterations in acute stroke that predispose patients to impaired perfusion and regulation of cerebral blood flow. To test this, we will target recruitment of acute ischemic stroke patients who present to the ED within 12 hours of symptoms onset. Enrolled subjects will receive continuous noninvasive hemodynamic monitoring contemporaneous with measurements of cerebral blood flow velocities and cerebral oximetry.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-02
• Study First Submitted: 2014-02-04
• Study First Submitted QC: 2014-02-04
• Study First Posted: 2014-02-06
• Primary Completion: 2016-05
• Study Completion: 2016-05
• Status Verified: 2017-01
• Last Update Submitted: 2017-01-02
• Last Update Posted: 2017-01-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

• Suspected ischemic stroke within 12 hours of symptom onset
• NIHSS ≥ 4
• Age 18 to 90 years

Exclusion Criteria

• Baseline modified Rankin Scale > 3
• Pregnancy
• Intracranial hemorrhage on head CT
• Mechanical ventilation prior to enrollment
• Inadequate temporal windows for TCD analysis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in cerebral blood flow velocities	initial 24 hours	Cerebral flow velocities determined by bilateral MCA measurements by TCD

Trial Locations

Locations (1)

Henry Ford Hospital; 🇺🇸 Detroit, Michigan, United States