Autoregulation of cerebral blood flow in patients after cardiac arrest

• Conditions: ischemic brain injury; postanoxic encephalopathy; 10014623

• Registration Number: NL-OMON42261
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

1. Comatose (Glasgow coma scale <= 8) after return of spontaneous circulation, after cardiac arrest
2. Presumed cardiac origin of the arrest

Exclusion Criteria

1. pregnancy;
2. thrombolytic therapy;
3. refractory cardiogenic shock;
4. life expectancy of < 24 hours;
5. history of chronic atrial fibrillation;
6. intra aortic balloonpump;
7. known carotid artery stenosis, or signs of carotid artery stenosis on physical examination or ultrasound

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>State of dynamic autoregulation as measured by the THRT, defined as impaired<br /><br>(THRR <= 1.09) or normal (THRR > 1.09) during the post-cardiac arrest syndrome. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Dynamic autoregulation using transfer function analysis of the transcranial<br /><br>Doppler signal<br /><br>Dynamic autoregulation using transfer function analysis of the NIRS signal </p><br>