MR Imaging of cerebral blood flow and autoregulation in patients with steno-occlusive vertebro-basilar artery disease.
Completed
- Conditions
- ischaemic cerebral strokestroke1000796310003216
- Registration Number
- NL-OMON36475
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
18 years or older.
Patients with ischaemic stroke or TIA in the perfusion territory of the vertebo-basilar arteries.
In case of stroke: a clinically stable situation.
Exclusion Criteria
Significant and symptomatic stenosis of the carotid arteries.
Pregnancy or possible pregnancy.
Implanted stent(s).
Severe liver or renal dysfunction.
Addison*s disease.
Allergic reaction for sulfonamides.
Cor pulmonale / heart failure (class III-IV) according to the NYHA classification.
Longobstruction / emfysema.
Primary hyperaldosteronisme.
Fenytoïne, primidon and/or fenobarbital use.
Japanese and Indian subjects or subjects of Japanese descent.
Impossibility to undergo MRI (claustrophobia, metal objects in or around the body).
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome is CVR measured with MR imaging at 3 Tesla using<br /><br>administration of vasodilatory challenge medication to induce hemodynamic<br /><br>stress.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary outcomes include cerebral blood flow (CBF) and CVR measured in the<br /><br>visual cortex, and differences in CBF and CVR between the recently symptomatic<br /><br>and asymptomatic patients.</p><br>